ArticleAnnals of medicine and surgery (2012)2025
The detrimental effect of autoimmune hepatitis in pregnancy: a systematic review and meta-analysis.
Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
10 authors.
Funding
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Abstract
Background: Autoimmune hepatitis (AIH), a chronic inflammatory liver disease, poses unique challenges during pregnancy. In AIH, the immune response triggers inflammation, potentially leading to cirrhosis if left untreated. The study aims to provide comprehensive insights into the relationship between AIH and pregnancy, guiding clinicians in optimal maternal management. Methods: Our meta-analysis includes data searched up to 1 January 2024. Eligibility criteria encompassed studies focusing on pregnant individuals with AIH, excluding case reports, letters, reviews, and incomplete papers. Data extraction, quality assessment using Cochrane risk of bias or Newcastle-Ottawa Scale, and quantitative analysis through Comprehensive Meta-Analysis were performed. Results: The literature search included 15 studies, involving 38 679 pregnant women with AIH across 10 countries. Maternal outcomes, such as disease flare [event rate ( Conclusion: This systematic review contributes a comprehensive overview of the complex interplay between AIH and pregnancy, providing evidence for heightened risks and implications on maternal and fetal outcomes. Clinicians can leverage these findings for informed decision-making, while the study enriches the broader field of autoimmune and reproductive health.
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