Evidence map›Paper›PMID 41377218›Full record

ArticleAnnals of medicine and surgery (2012)2025

Gut-brain axis and Parkinson's disease: navigating the microbial enigma.

Muhammad Soban Jaffer, Saad Sohail, Nouman Ahmed, Ayesha Ashraf, Elham Shenawa

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Muhammad Soban JafferDepartment of Medicine, Services Institute of Medical Sciences, Lahore, Pakistan.
Saad SohailDepartment of Medicine, King Edward Medical University, Lahore, Pakistan.
Nouman AhmedDepartment of Medicine, King Edward Medical University, Lahore, Pakistan.
Ayesha AshrafDepartment of Medicine, King Edward Medical University, Lahore, Pakistan.
Elham ShenawaBalkh University Faculty of Medicine, Balkh University, Balkh, Afghanistan.ORCID https://orcid.org/0009-0002-7582-2490

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD), traditionally seen as a Central Nervous System (CNS) disorder with dopaminergic neuron loss and α-synuclein aggregation, increasingly implicates the gut-brain axis in its pathogenesis. Gut microbiota dysbiosis precedes motor symptoms by years, linking to non-motor issues like constipation and rapid eye movement sleep behavior disorder, with reduced neuroprotective bacteria (e.g.,

Identifiers

PMID41377218
PMCPMC12689100

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.