Trial reportFrontiers in human neuroscience2025
Rehabilitation of patients in the subacute phase of stroke using the ReHand robotic system: a randomized controlled trial.
Trial report in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06937346 (Robotic-Assisted Upper Limb Rehabilitation After Stroke Using the ReHand System), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Robotic-Assisted Upper Limb Rehabilitation After Stroke Using the ReHand System: A Randomized Controlled Trial
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Upper limb motor impairment after stroke is a major cause of limitations in daily activities and reduced quality of life. Although traditional rehabilitation is effective, it is often insufficiently intensive and lacks focus on fine motor activation. Portable soft exoskeletons offer a promising approach to intensify recovery. This trial aimed to evaluate the effectiveness of the ReHand robotic system in subacute stroke rehabilitation. Methods: This Randomized Controlled Trial (RCT) included 120 patients in the subacute period of stroke. Participants were stratified by age and motor deficit severity and randomized into the intervention group (robotic therapy + standard therapy) or control group (standard therapy only). The intervention was delivered 5 times per week over 8 weeks. The primary outcome was change in Fugl-Meyer Assessment for Upper Extremity (FMA-UE); secondary outcomes included Barthel Index (BI), Functional Independence Measure (FIM), National Institutes of Health Stroke Scale (NIHSS), modified Wolf Motor Function Test (mWMFT), Frenchay Arm Test (FAT), Disabilities of the Arm, Shoulder and Hand (DASH), and Hospital Anxiety and Depression Scale (HADS). Statistical analysis was performed in Python (v3.11). Normality was assessed with the Shapiro-Wilk test; the Mann-Whitney test was used for intergroup comparisons; Pearson's χ Results: The intervention group demonstrated significantly greater improvements in upper limb motor impairment compared to the control group, as reflected by larger gains in FMA-UE scores. Clinically meaningful improvements (≥5.25 points) were observed in 91.7% of patients in the intervention group versus 43.3% in the control group. All secondary outcomes also showed significant improvements in the intervention group ( Conclusion: When combined with standard therapy, the ReHand robotic system may enhance upper limb recovery after stroke and appears to be a safe and feasible adjunct to multidisciplinary rehabilitation programs. Clinical trial registration: ClinicalTrials.gov, identifier (NCT06937346).
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