Evidence map›Paper›PMID 41377165›Full record

ArticleJournal of clinical and translational research2025

Association between serum uric acid and prostate cancer risk: The modifying role of

Randi Chen, Timothy A Donlon, Richard C Allsopp, Brian J Morris, Bradley J Willcox, Kamal H Masaki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Randi ChenDepartment of Research, Kuakini Japan-Hawaii Cancer Study, Kuakini Honolulu Heart Program, Center of Biomedical Research Excellence (COBRE) for Clinical and Translational Research on Aging, Kuakini Medical Center, Honolulu, Hawaii, United States of America.ORCID 0000-0003-3747-7964
Timothy A DonlonDepartment of Research, Kuakini Japan-Hawaii Cancer Study, Kuakini Honolulu Heart Program, Center of Biomedical Research Excellence (COBRE) for Clinical and Translational Research on Aging, Kuakini Medical Center, Honolulu, Hawaii, United States of America.ORCID 0000-0001-6545-6533
Richard C AllsoppDepartment of Anatomy, Biochemistry and Physiology, Institute for Biogenesis Research, University of Hawaii, Honolulu, Hawaii, United States of America.ORCID 0000-0001-7565-5325
Brian J MorrisDepartment of Research, Kuakini Japan-Hawaii Cancer Study, Kuakini Honolulu Heart Program, Center of Biomedical Research Excellence (COBRE) for Clinical and Translational Research on Aging, Kuakini Medical Center, Honolulu, Hawaii, United States of America.ORCID 0000-0003-2468-3566
Bradley J WillcoxDepartment of Research, Kuakini Japan-Hawaii Cancer Study, Kuakini Honolulu Heart Program, Center of Biomedical Research Excellence (COBRE) for Clinical and Translational Research on Aging, Kuakini Medical Center, Honolulu, Hawaii, United States of America.ORCID 0000-0001-9890-3520
Kamal H MasakiDepartment of Research, Kuakini Japan-Hawaii Cancer Study, Kuakini Honolulu Heart Program, Center of Biomedical Research Excellence (COBRE) for Clinical and Translational Research on Aging, Kuakini Medical Center, Honolulu, Hawaii, United States of America.ORCID 0000-0003-1170-3118

Funding

Epidemiology of Brain Aging in the Very OldU01AG019349 · NIA · KUAKINI MEDICAL CENTER · PI WHITE, LON RAY · 2001 to 2011
$14.0M
Productive and Leisure Activities and Cognition in Later LifeP20GM125526 · NIGMS · KUAKINI MEDICAL CENTER · PI LEE, YEONJUNG · 2019 to 2023
$12.0M
FOXO3 Genotype, InflammAging, Cardiovascular Disease, and Dementia. Kuakini Hawaii Lifespan Study III. Administrative Supplement.R01AG027060 · NIA · KUAKINI MEDICAL CENTER · PI Gregory J. Tranah, BRADLEY JOHN WILLCOX · 2005 to 2026
$8.1M
Energy-sensing Pathways, Healthy Aging and LongevityR01AG038707 · NIA · KUAKINI MEDICAL CENTER · PI WILLCOX, BRADLEY JOHN · 2011 to 2014
$1.4M
HONOLULU HEART PROGRAMN01HC005102 · HC · KUAKINI MEDICAL CENTER · PI CURB, JESS DAVID · 1990 to 1997
–
NHLBI NIH HHS N01 HC005102NIA NIH HHS R01 AG027060NIA NIH HHS R01 AG038707NIA NIH HHS U01 AG019349NIGMS NIH HHS P20 GM125526
6 · The paper itself

Abstract

Background: The role of uric acid in prostate cancer risk remains uncertain, with evidence suggesting both carcinogenic and protective effects. Genetic factors may be key modifiers of this association. Objective: This study aimed to determine whether the relationship between uric acid and prostate cancer risk differs by the Methods: We examined 6,259 Japanese-American men in Hawaii, cancer-free at baseline (1965-1968, ages 45-68), who were followed for incident prostate cancer until 1999. Hyperuricemia was defined as serum uric acid ≥7.0 mg/dL. Results: During a median follow-up of 29.7 years, 285 prostate cancer cases were identified. A significant interaction between Conclusion: The association between uric acid and prostate cancer varied by Relevance to patients: Monitoring and lowering serum uric acid may help reduce prostate cancer risk in men with the

Indexed as

Connective tissue growth factorCTGFGene-environment interactionHyperuricemiaProstate cancerUric acid

Identifiers

PMID41377165
PMCPMC12687944

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.