Evidence map›Paper›PMID 41377120›Full record

ArticleComputational and structural biotechnology journal2025

CirRFKB: A knowledgebase of circadian-related risk factors for cancer pathogenesis and personalized medicine.

Jiao Wang, Hui Zong, Yingbo Zhang, Xingyun Liu, Ke Shen, Xiaoyu Li, Rongrong Wu, Min Jiang, Daniel Rivero Cebrián, Juan Ramón Rabuñal Dopico and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jiao WangCancer center and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.
Hui ZongCancer center and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.
Yingbo ZhangCancer center and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.
Xingyun LiuCancer center and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.
Ke ShenCancer center and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.
Xiaoyu LiCancer center and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.
Rongrong WuCancer center and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.
Min JiangCancer center and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.
Daniel Rivero CebriánDepartment of Computer Science and Information Technology, University of A Coruña, A Coruña 15001, Spain.
Juan Ramón Rabuñal DopicoDepartment of Computer Science and Information Technology, University of A Coruña, A Coruña 15001, Spain.
Bairong ShenCancer center and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circadian rhythms regulate numerous physiological and biochemical processes in humans, and their disruption is linked to elevated cancer risk and progression. Although substantial research has elucidated interactions between circadian mechanisms and cancer pathways, these findings remain fragmented and poorly integrated, impeding a holistic understanding. To address this gap, we developed the Circadian-Related Risk Factor Knowledgebase for Cancer (CirRFKB), a manually curated repository documenting validated associations between the circadian clock and cancer. CirRFKB curates data from 471 articles, encompassing 46 cancer types and 4052 records, categorizing risk factors into 1449 single factors and 340 combinations. Single factors were categorized into 681 genetic factors, 106 environmental factors, 244 physiological factors, and 418 behavioral factors. These factors were further classified as 254 protective factors, 323 risk factors, 291 no-influencing factors, and 921 unclear factors. The user-friendly interface enables researchers to explore, visualize, and retrieve data through comprehensive browsing and query tools. CirRFKB provides a foundational resource that structures circadian-cancer interactions, offering systematic evidence to advance clinical applications in deep phenotyping for precision oncology and the optimization of chronotherapy. CirRFKB is publicly accessible at: http://bioinf.org.cn:9876/.

Indexed as

CancerCircadian clockKnowledgebasePersonalized treatmentRisk factors

Identifiers

PMID41377120
PMCPMC12686628

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.