ArticleEuropean heart journal open2025
Association of ankle-brachial Index with coronary and extra-coronary calcification in older adults: ARIC study.
Article in European heart journal open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Changes in Cardiac-Arterial Coupling After Cardiac Surgery for Aortic Valve Disease.Reviews in cardiovascular medicine · 2026Article
- First quinquennium completed: highlights fromEuropean heart journal open · 2026Article
- Decoding the ankle-brachial index in peripheral artery disease: coronary versus valvular calcification.European heart journal open · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Aims: To investigate potentially distinct associations of ankle brachial index (ABI), a marker of subclinical atherosclerosis, with calcification in different vascular beds and cardiac valves. Methods and results: We studied 1420 ARIC participants (mean age 80.2 [SD 4.1] years, 60.2% female, and 16.6% Blacks). ABI was measured at visit 6 (2016-17) or visit 7 (2018-19), and coronary artery calcification (CAC) and extra-coronary calcification (thoracic aorta, aortic valve, and mitral valve) were assessed through non-contrast cardiac-gated computed tomography. We ran multivariable logistic regression models, with any (Agatston score >0) and high (≥75th percentile) calcification as primary and secondary outcome variables, respectively. For any calcification, ABI ≤0.9 had the strongest association with any CAC (odds ratio 9.51 [95%CI 1.26, 71.84]), followed by descending aorta calcification (6.01 [1.36, 26.56]), and weakest for cardiac valve calcification. Using high calcification as an outcome, ABI ≤0.9 was significantly associated with all vascular and valvular calcification tested, but weakest for aortic valve. High ABI [>1.3] tended to be more strongly associated with valvular calcification than vascular calcification with any calcification as an outcome. Conclusion: Low ABI was most robustly associated with CAC. Its association was weaker for thoracic aorta calcification and weakest for valvular calcification. These findings further support distinct pathophysiology of calcification across vascular beds and cardiac valves.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.