Evidence map›Paper›PMID 41377035›Full record

ArticleAmerican heart journal plus : cardiology research and practice2026

A Pragmatic Trial Evaluating the Impact of the Anumana Clinical Decision Support Tool for Guideline-Directed Management of Heart Failure (ACT-HF): Clinical trial design and methods.

Francisco Lopez-Jimenez, Heather M Alger, Sarah P Hackett, Vinay Gundurao, Ketan Mehta, Prerak Jain, Praveen Kumar-M, Chinmay Padhye, Arjun Puranik, Kitzner Vassor and 11 more

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In one paragraph

Article in American heart journal plus : cardiology research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Francisco Lopez-JimenezMayo Clinic, Rochester, MN, USA.
Heather M AlgerAnumana, Inc., Cambridge, MA, USA.
Sarah P HackettAnumana, Inc., Cambridge, MA, USA.
Vinay GunduraoAnumana, Inc., Cambridge, MA, USA.
Ketan MehtaAnumana, Inc., Cambridge, MA, USA.
Prerak JainAnumana, Inc., Cambridge, MA, USA.
Praveen Kumar-MAnumana, Inc., Cambridge, MA, USA.
Chinmay PadhyeAnumana, Inc., Cambridge, MA, USA.
Arjun PuranikAnumana, Inc., Cambridge, MA, USA.
Kitzner VassorAnumana, Inc., Cambridge, MA, USA.
Sunil Kumar RaviAnumana, Inc., Cambridge, MA, USA.
Barbara BarryMayo Clinic, Rochester, MN, USA.
Ranee ChatterjeeDuke University School of Medicine, Durham, NC, USA.
Chen ChowStormont Vail Health, Topeka, KS, USA.
Rowena DolorDuke University School of Medicine, Durham, NC, USA.
Stephen J GreeneDivision of Cardiology, Duke University School of Medicine, Durham, NC, USA.
Grace LinMayo Clinic in Florida, Jacksonville, FL, USA.
David RushlowMayo Clinic, Rochester, MN, USA.
Mark StampehlNovartis Pharmaceuticals Corp, East Hanover, NJ, USA.
Xuan ZhuMayo Clinic, Rochester, MN, USA.
Samir AwasthiAnumana, Inc., Cambridge, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Heart failure with reduced ejection fraction (HFrEF) is progressive and pervasive. Guidelines provide evidence-based recommendations to manage HFrEF, yet adherence to Guideline Directed Medical Therapy (GDMT) is low. An opportunity exists to improve adherence by delivering actionable data, reducing clinician information overload, and enhancing patient care. A Pragmatic Trial Evaluating the Impact of the Anumana Clinical Decision Support Tool for Guideline-Directed Management of Heart Failure (ACT-HF) will evaluate a clinical decision support software (CDSS) that integrates in electronic health records (EHR), automates chart review, and identifies care gaps. Methods: Anumana's Guideline Navigator is an innovative, multi-module AI-enabled CDSS with automated chart review to rapidly analyze EHR data, detect care gaps, and provide alerts for eligible patients not receiving optimal GDMT. ACT-HF, a multi-center cluster pragmatic trial, will recruit and randomize clinician participants (≤250) from 2 health systems to receive intervention software or provide usual care. The trial will evaluate outpatient care for adults with documented HFrEF and not on optimal GDMT (>2148). Outcomes will be evaluated at 90 days. Clinician participants may discuss results with patients, but patients will not have access to the CDSS. Results: Primary outcome is change in GDMT medications; exploratory endpoints include clinical outcomes, resource utilization, and usability. Subgroup analyses include health system, clinician, and patient-level characteristics associated with outcomes. Conclusion: Building on efforts to improve GDMT adherence, ACT-HF will test Anumana's Guideline Navigator in a multicenter study to evaluate outcomes and further refine the CDSS EHR integration EHR for improved clinical utility, workflow integration, and patient outcomes.

Indexed as

Artificial intelligenceBest practice alertsClinical decision supportElectronic health recordGuideline directed medical therapyHeart failureNatural language processing

Identifiers

PMID41377035
PMCPMC12689177

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.