ArticleJournal of thoracic disease2025
Hepatocyte growth factor alleviates alcoholic cardiomyopathy through the Nrf2 pathway-a focus on iron metabolism.
Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- The role of programmed cell death in chronic obstructive pulmonary disease: from pathogenesis to treatment.Frontiers in immunology · 2026Review
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Authors and funding
4 authors.
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Abstract
Background: Alcohol misuse leads to cardiomyopathy. Hepatocyte growth factor (HGF) concentrations and iron metabolism fluctuations are both associated with cardiovascular diseases. This investigation is designed to test if and how HGF regulates cardiac ferroptosis. Methods: Male Sprague Dawley rats were used to establish animal models. Exogenous HGF's potential to reduce cardiomyocyte ferroptosis, which is typified by varying labile iron pool (LIP), elevated lipid peroxidation, and diminished cell survival, was examined by fluorescence quantification, enzyme-linked immunosorbent assay (ELISA), Cell Counting Kit-8 (CCK8) and calcein staining. Nuclear factor erythroid 2-related factor 2 ( Results: HGF suppressed cardiac ferroptosis through Conclusions: HGF functions as a potent protective factor for alcoholic cardiomyopathy (ACM) by inhibiting cardiac ferroptosis via
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