ArticleJournal of thoracic disease2025
Serum electrolytes as prognostic markers: a new frontier in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) management.
Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide, and acute exacerbation of COPD (AECOPD) is the most common cause of hospitalization in these patients. This study demonstrated for the first time that serum sodium and calcium imbalances are independent predictors of AECOPD prognosis and explored the relationship between serum electrolyte levels and the prognosis of patients with AECOPD. Methods: This retrospective study included 535 AECOPD patients admitted to The First Hospital of Lanzhou University between October 2021 and May 2023. Serum electrolyte levels, specifically sodium ion and calcium ion levels, were considered exposure variables, whereas AECOPD prognosis was defined as the presence or absence of readmission within 1 year. Logistic regression and Cox regression analyses were used to evaluate the associations between serum sodium and calcium levels and the risk of readmission within 1 year, supplemented by subgroup analysis, sensitivity analysis, and Kaplan-Meier survival analysis. Results: Compared with patients not readmitted within 1 year, readmitted patients had lower sodium (Na Conclusions: Serum sodium and calcium levels are independently associated with 1-year readmission risk in AECOPD patients, and early detection and management of sodium and calcium imbalances may improve clinical outcomes. To establish a causal relationship and further explore the interaction of pathophysiological mechanisms, multicenter prospective studies are warranted.
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