Evidence map›Paper›PMID 41376968›Full record

ArticleJournal of thoracic disease2025

Impact of preoperative left ventricular diastolic dysfunction on primary graft dysfunction and mortality following lung transplantation.

Shixiao Tang, Xinyu Feng, Jieyu Hua, Mingyue Chen, Ke Wang, Shuai Miao, Jingjing Xu, Min Dai, Sijia Gu, Xiao Liang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shixiao Tang *Department of Anesthesiology and Pain Medicine, The Affiliated Wuxi No.2 People's Hospital Clinical College of Xuzhou Medical University, Jiangnan University Medical Center, Wuxi No.2 People's Hospital, Wuxi, China.
Xinyu Feng *Department of Anesthesiology and Pain Medicine, The Affiliated Wuxi No.2 People's Hospital Clinical College of Xuzhou Medical University, Jiangnan University Medical Center, Wuxi No.2 People's Hospital, Wuxi, China.
Jieyu Hua *Department of Anesthesiology and Pain Medicine, The Affiliated Wuxi No.2 People's Hospital Clinical College of Xuzhou Medical University, Jiangnan University Medical Center, Wuxi No.2 People's Hospital, Wuxi, China.
Mingyue Chen *Department of Anesthesiology and Pain Medicine, The Affiliated Wuxi No.2 People's Hospital Clinical College of Xuzhou Medical University, Jiangnan University Medical Center, Wuxi No.2 People's Hospital, Wuxi, China.
Ke WangDepartment of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, China.
Shuai MiaoDepartment of Anesthesiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, China.
Jingjing XuDepartment of Anesthesiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, China.
Min DaiDepartment of Anesthesiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, China.
Sijia GuDepartment of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai, China.
Xiao LiangDepartment of Anesthesiology and Pain Medicine, The Affiliated Wuxi No.2 People's Hospital Clinical College of Xuzhou Medical University, Jiangnan University Medical Center, Wuxi No.2 People's Hospital, Wuxi, China.
Yiling QianDepartment of Anesthesiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, China.
Chunxiao HuDepartment of Anesthesiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, China.
Dongxiao HuangDepartment of Anesthesiology and Pain Medicine, The Affiliated Wuxi No.2 People's Hospital Clinical College of Xuzhou Medical University, Jiangnan University Medical Center, Wuxi No.2 People's Hospital, Wuxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Lung transplantation (LTx) is a definitive treatment for end-stage lung disease, yet primary graft dysfunction (PGD) remains a major cause of early postoperative morbidity and mortality. Left ventricular diastolic dysfunction (LVDD) is common in these patients, but its impact on PGD and survival remains unclear. This study aimed to determine whether preoperative LVDD increases the risk of PGD and 1-year mortality after LTx. Methods: A retrospective cohort study was conducted, involving 344 patients who underwent LTx in Wuxi People's Hospital from January 1, 2018, to June 22, 2021. Regression models were utilized to examine the effects of LVDD and transthoracic echocardiography (TTE) parameters on PGD or 1-year mortality risk. The predictive performance of various cardiac indicators for PGD was evaluated using the area under the curve (AUC). Results: LVDD [odds ratio (OR) 2.099, 95% confidence interval (CI) 1.071-4.116, P=0.03] and e'<10 cm/s (OR 2.139, 95% CI: 1.177-3.889, P=0.01) were independently associated with a higher risk of PGD. In multivariate analysis, LVDD was not associated with higher 1-year mortality risk (hazard ratio 1.638, 95% CI: 1.129-2.375, P=0.009). The clinical threshold for e' to predict PGD was determined to be 9.85 cm/s, with a sensitivity of 67% and specificity of 48%. Conclusions: Preoperative LVDD significantly increases the risk of PGD following LTx. LVDD was not an independent risk factor for postoperative 1-year mortality. Future prospective clinical studies are required to validate LVDD as a risk factor for post-LTx PGD and to further investigate whether LVDD impacts mortality through mediator effects.

Indexed as

left ventricular diastolic dysfunction (LVDD)Lung transplantation (LTx)primary graft dysfunction (PGD)

Identifiers

PMID41376968
PMCPMC12688495

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.