ArticleJournal of thoracic disease2025
Effects of driving pressure-guided lung-protective ventilation strategy on respiratory mechanics, oxygenation, and postoperative pulmonary complications in patients undergoing minimally invasive esophagectomy: a randomized clinical trial.
Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Driving pressure-guided ventilation during one-lung ventilation for thoracic surgery: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- One-lung ventilation with intentional closure of the nonventilated lumen in a patient with giant pulmonary bullae undergoing laparoscopic anterior resection: a case report.AME case reports · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Minimally invasive Ivor Lewis esophagectomy (MIE) is a primary treatment option for esophageal cancer. However, intraoperative pneumoperitoneum and one-lung ventilation (OLV) significantly alter respiratory mechanics, potentially leading to hypoxemia and postoperative pulmonary complications (PPCs). The objective of this study was to evaluate the effects of a driving pressure (DP)-guided lung-protective ventilation strategy on respiratory mechanics, oxygenation levels, and the occurrence of PPCs in patients undergoing MIE. Methods: This study was a single-center, prospective, randomized controlled clinical trial. Sixty patients undergoing MIE were randomly assigned to either a conventional lung-protective ventilation strategy group (VC group) or a DP-guided lung-protective ventilation strategy group (VD group). In the VC group, positive end-expiratory pressure (PEEP) was set at a fixed level of 5 cmH Results: A total of 59 patients were analyzed, including 30 in the VC group and 29 in the VD group. The VD group showed significantly higher Cdyn than the VC group, especially at 30 min after OLV (median difference of 9.0 mL/cmH Conclusions: In patients undergoing MIE, implementing a DP-guided lung-protective ventilation strategy significantly improved intraoperative respiratory mechanics and oxygenation parameters while maintaining relatively stable hemodynamics, but failed to reduce clinically relevant outcomes such as PPCs within 7 days. Trial Registration: This study was registered at Chinese Clinical Trial Registry (ChiCTR2400089494).
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