ArticleJournal of thoracic disease2025
Comparison of metagenomic next-generation sequencing (mNGS) technology with routine laboratory culture for bacterial and fungal detection in bronchoalveolar lavage fluid.
Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Postoperative Nocardia cyriacigeorgica infection after glioblastoma resection: correlating metagenomic next-generation sequencing with conventional microbiology.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Pulmonary infections continue to threaten human health. Metagenomic next-generation sequencing (mNGS) technology provides a rapid detection method for identifying the pathogens responsible for pulmonary infections, with many advantages compared to traditional culture method. Our objective is to collect and analyze testing data from patients with pulmonary infections at the Department of Respiratory Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, in order to compare the detection rates of mNGS and traditional culture method. Methods: This study conducted a retrospective analysis of bronchoalveolar lavage fluid (BALF) samples from 50 patients with pulmonary infections at the Department of respiratory medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, comparing the differences between mNGS and the traditional "gold standard" culture method. Results: The detection rate of mNGS for fungi or bacteria was 72.0% (36/50), while that of culture method was 12.0% (6/50). According to the McNemar χ Conclusions: mNGS, as a new diagnostic testing technology, has significant advantages in identifying bacteria, fungi, and virus. The combination of mNGS analysis of BALF and traditional pathogen culture method can improve the efficiency of pathogen detection and facilitate the diagnosis of patients with pulmonary infections, allowing patients to receive targeted treatment as soon as possible.
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