ArticleJournal of thoracic disease2025
A retrospective study with whole-exome sequencing of tissue samples: analysis of risk factors in patients of persistent cough following lung segmentectomy.
Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Persistent cough after pulmonary resection (CAP) is one of the most common postoperative complications in patients with non-small cell lung cancer (NSCLC) and can impair postoperative recovery and quality of life. While several clinical and surgical risk factors have been identified, the genetic basis of CAP remains unclear. Whole-exome sequencing (WES) allows comprehensive detection of coding-region mutations and may help uncover molecular markers associated with CAP. This retrospective cohort study investigated the association between gene mutations identified by WES and CAP in patients with NSCLC. Methods: Twenty NSCLC patients who underwent surgery were enrolled and categorized into a cough group (n=9) and a non-cough group (n=11) using the Leicester Cough Questionnaire-Mandarin Chinese version (LCQ-MC). Postoperative tissue samples were collected for WES. Clinical data were analyzed to assess the incidence of CAP and related clinical characteristics. Genetic mutations were identified through WES, and a logistic regression model was applied to determine potential risk factors for CAP. Results: Chi-squared tests identified significant associations between CAP and preoperative cough, as well as mutations in the Conclusions: The
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