Evidence map›Paper›PMID 41376857›Full record

ReviewGenes & diseases2026

The advancements in organoids: Potential and challenges in researching the esophagus and esophageal squamous cell carcinoma.

Xinxin Li, Zhuo Wang, Yongpan Liu, Jiaying Zhang, Lijia Zhang, Yi Li, Xiaolu An, Yihui Yang, Ruixuan Yu, Meng Zhao and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genes & diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xinxin LiCentral Laboratory, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China.
Zhuo WangCentral Laboratory, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China.
Yongpan LiuSchool of Life Science, Xiamen University, Xiamen, Fujian 361102, China.
Jiaying ZhangCentral Laboratory, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China.
Lijia ZhangCentral Laboratory, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China.
Yi LiDepartment of Cardio-Thoracic Surgery, The 900th Hospital of the Joint Logistic Support Force, People's Liberation Army, Fuzhou, Fujian 350025, China.
Xiaolu AnCentral Laboratory, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China.
Yihui YangSchool of Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.
Ruixuan YuCollege of Health Caring Industry of Harbin Medical University (Daqing), Daqing, Heilongjiang 163711, China.
Meng ZhaoInstitute for Laboratory Medicine, The 900th Hospital of the Joint Logistic Support Force, People's Liberation Army, Fuzhou, Fujian 350025, China.
Kuancan LiuCentral Laboratory, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Esophageal squamous cell carcinoma (ESCC) ranks among the top six deadliest malignancies globally, characterized by an alarmingly low five-year survival rate. This aggressive cancer is especially prevalent in Asian countries, where it is strongly influenced by various factors, including dietary habits. Organoids, a novel bioresource that are three-dimensional, miniature organ-like structures derived from stem cells or cancer cells in a laboratory, closely mimics the architecture and function of actual organs, providing an enhanced model for

Indexed as

Disease modellingDrug screenEsophageal squamous cell carcinomaEsophagusOrganoid

Identifiers

PMID41376857
PMCPMC12688692

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.