ReviewGenes & diseases2026
RNA modifications in intestinal macrophages: Implications for gut immunity and inflammation.
Review in Genes & diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Targeting the Gut-Brain-Ferroptosis Axis: Molecular Mechanisms and Therapeutic Potential in Alzheimer's Disease and Epilepsy.Journal of molecular neuroscience : MN · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intestinal macrophages are critical regulators of mucosal immunity, playing essential roles in microbial surveillance, barrier maintenance, and tissue repair. As highly responsive immune cells, they integrate diverse environmental cues to dynamically adapt to their functional states. In recent years, RNA modifications have emerged as a key layer of post-transcriptional regulation, orchestrating macrophage development, polarization, and immunometabolic programming. This review focuses on the role of epitranscriptomic regulation in shaping the plasticity of intestinal macrophages, systematically summarizing how RNA modifications influence their responses to inflammatory stimuli, microbial signals, and intercellular communication. We further highlight the regulatory potential of RNA modifications in gut immune homeostasis and inflammatory diseases, providing a comprehensive framework for understanding RNA-mediated immune regulation and a forward-looking perspective on targeting these pathways in intestinal disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.