Evidence map›Paper›PMID 41376825›Full record

ArticleJournal of diabetes research2025

Exome Sequencing of a Type 1 Diabetes Mellitus Family Exposes Both Common and Individualized Rare Variants Contributing to Pathogenesis.

Tomader A M Ibrahim, Rayan S Ali, Mohamed A Abdullah, Muntaser E Ibrahim

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In one paragraph

Article in Journal of diabetes research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tomader A M IbrahimDepartment of Molecular Biology, Institute of Endemic Diseases, Medical Campus, University of Khartoum, Khartoum, Sudan.ORCID https://orcid.org/0000-0002-3794-7244
Rayan S AliDepartment of Molecular Biology, Institute of Endemic Diseases, Medical Campus, University of Khartoum, Khartoum, Sudan.ORCID https://orcid.org/0000-0002-2582-655X
Mohamed A AbdullahDepartment of Paediatrics, Faculty of Medicine, Medical Campus, University of Khartoum, Khartoum, Sudan.ORCID https://orcid.org/0000-0001-7121-8216
Muntaser E IbrahimDepartment of Molecular Biology, Institute of Endemic Diseases, Medical Campus, University of Khartoum, Khartoum, Sudan.ORCID https://orcid.org/0000-0003-2242-2143

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 1 diabetes mellitus (T1D) is a disease of complex inheritance where genetic, immunological, and environmental factors interact in rendering the ultimate phenotype. To gain insights into the molecular etiology of the disease in a subset of a population that is sparsely investigated in genetic terms, like in Africa, exome sequence data from a T1D multicase family and a T1D cohort were investigated. The exome analysis identified several candidate genes related to T1D, like human leukocyte antigen (HLA), insulin (INS) gene, Cytotoxic T-lymphocyte-Associated Protein 4 (CTLA4), Protein Tyrosine Phosphatase Nonreceptor Type 22 (PTPN22), and Interferon-Induced Helicase C Domain 1 (IFIH1). A total of eight pathways were significantly overrepresented (

Indexed as

Diabetes Mellitus, Type 1ExomeAdolescentAdultCase-Control StudiesChildExome SequencingFemaleGenetic Predisposition to DiseaseGenetic VariationHepatocyte Nuclear Factor 1-alphaHepatocyte Nuclear Factor 4HumansMalePedigreePhenotypeHepatocyte Nuclear Factor 1-alphaHepatocyte Nuclear Factor 4HNF1A protein, humanHNF4A protein, humancommon variantsDiabetes Type 1exome sequencingindividualizedMicroRNArare variants

Identifiers

PMID41376825
PMCPMC12688644

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.