Evidence map›Paper›PMID 41376812›Full record

ArticleFrontiers in aging neuroscience2025

Multimodal MRI reveals distinct hippocampal subregional alterations in

Chenxi Pan, Enchun Zhao, Jingru Ren, Gaiyan Zhou, Yajie Wang, Ronggui Zhang, Yang Shen, Weiguo Liu, Jiu Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chenxi Pan *Department of Anorectal, Huai'an TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Huai'an, China.
Enchun Zhao *Department of Anorectal, Huai'an TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Huai'an, China.
Jingru Ren *Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Gaiyan ZhouDepartment of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Yajie WangDepartment of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Ronggui ZhangDepartment of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Yang ShenDepartment of Neurology, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, The Central Hospital of Xiaogan, Xiaogan, China.
Weiguo LiuDepartment of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Jiu ChenDepartment of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hippocampal subregion atrophy has been associated with cognitive decline in Parkinson's disease (PD). Our study aimed to investigate the functional and structural alterations of the hippocampal subregion in newly diagnosed PD patients presenting with different cognitive states and to explore potential associations between these neuroanatomical alterations and cognitive performance. Methods: A total of four participant groups were recruited, including a Results: Compared to the PD-NC, the PD-SCD group revealed a significantly decreased FC between the left middle hippocampus (HIPm) and right postcentral gyrus (PoCG. R). Patients in the PD-MCI group had a decreased FC value not only between HIPm and PoCG. R but also between the left anterior hippocampus (HIPa) and PoCG. R. The GM volume in HIPa of PD-NC patients was significantly higher than that of PD-MCI patients. Furthermore, partial correlation analysis indicated that the FC in HIPa-PoCG. R and HIPm-PoCG. R was positively associated with executive functions. The elevated GM volume in HIPa was associated with better visuospatial and language functions. Conclusion: Dysfunction of left HIPm may contribute to initial executive decline in PD. The different subregions of the long-axis hippocampus could be targeted for early intervention strategies in PD with different cognitive states in the future.

Indexed as

hippocampal subregionmild cognitive impairmentMRIParkinson’s diseasesubjective cognitive decline

Identifiers

PMID41376812
PMCPMC12685818

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.