Evidence map›Paper›PMID 41376775›Full record

ArticleMolecular therapy. Methods & clinical development2025

Retinal organoids mirror CRISPR-Cas9 gene editing efficiency observed

Juliette Pulman, Hugo Malki, Paul Oudin, Ecem Aydin, Sophie Tran, Laura Visticot, Camille Robert, Anne De Cian, Marie As, Olivier Goureau and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Juliette PulmanSorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012 Paris, France.
Hugo MalkiSorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012 Paris, France.
Paul OudinSorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012 Paris, France.
Ecem AydinSorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012 Paris, France.
Sophie TranSorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012 Paris, France.
Laura VisticotSorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012 Paris, France.
Camille RobertSorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012 Paris, France.
Anne De CianLaboratoire Structure et Instabilité des Génomes, INSERM U1154, CNRS 7196, Muséum National d'Histoire Naturelle, CP26 43 rue Cuvier 75231 Paris Cedex 05, France.
Marie AsLaboratoire Structure et Instabilité des Génomes, INSERM U1154, CNRS 7196, Muséum National d'Histoire Naturelle, CP26 43 rue Cuvier 75231 Paris Cedex 05, France.
Olivier GoureauSorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012 Paris, France.
Jean-Paul ConcordetLaboratoire Structure et Instabilité des Génomes, INSERM U1154, CNRS 7196, Muséum National d'Histoire Naturelle, CP26 43 rue Cuvier 75231 Paris Cedex 05, France.
Deniz DalkaraSorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012 Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human retinal organoids are

Indexed as

AAVCRISPR-Cas9gene editinggene therapyhuman retinal organoidsmodelsmousephotoreceptorsretinaRNP

Identifiers

PMID41376775
PMCPMC12686912

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.