Evidence map›Paper›PMID 41376772›Full record

ArticleFrontiers in neurology2025

Effect of general anesthesia vs. local anesthesia and collateral status on outcomes in anterior circulation occlusion.

Guojie Chen, Rundong Chen, Tianxiang Gao, Lijun Wang, Hongye Xu, Wen Yin, Yu Gao, Lei Zhang, Yongxin Zhang, Pengfei Xing and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Guojie Chen *Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Rundong Chen *Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Tianxiang Gao *Department of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, China.
Lijun WangNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Hongye XuNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Wen YinNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Yu GaoNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Lei ZhangNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Yongxin ZhangNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Pengfei XingNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Pengfei YangNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Zifu LiNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Yongwei ZhangNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Jianmin LiuNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and objectives: The impact of anesthesia type on outcomes following endovascular thrombectomy (EVT) remains controversial. Collateral status assessed through perfusion imaging may provide critical insights for optimizing anesthesia strategies during EVT. Methods: In this retrospective cohort study, functional outcomes after EVT (measured by the modified Rankin Scale score) were compared between general anesthesia (GA) vs. local anesthesia (LA) using a propensity score-matched model. The association between the hypoperfusion intensity ratio (HIR, defined as Tmax > 10s/Tmax > 6 s) and outcomes was evaluated through weighted multivariate logistic regression, with potential non-linearity explored using restricted cubic spline (RCS) regression. To validate the findings, five analytical approaches were applied, including propensity score matching, multivariate logistic modeling adjusted for all covariates, inverse probability of treatment weighting (IPTW), and doubly robust estimations with and without adjustments for unbalanced covariates. Results: A total of 702 patients were included, with 327 (46.6%) receiving GA and 375 (53.4%) receiving LA. Propensity score matching achieved balanced baseline characteristics ( Conclusions: There is an association between general anesthesia and poorer functional prognosis in patients with well-developed collateral circulation after endovascular thrombectomy (EVT). HIR may serve as a useful marker for anesthesia selection and triage in EVT. Classification of evidence: This study provides Class III evidence that use of GA is associated with worse functional outcome in patients with good collateral that undergoing EVT.

Indexed as

acute ischemic strokeanesthesiacollateral statusendovascular treatmentfunctional independencepropensity score matching

Identifiers

PMID41376772
PMCPMC12685674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.