Evidence map›Paper›PMID 41376758›Full record

ArticleCureus2025

Misleading Markers: Troponin-Positive Spontaneous Pneumomediastinum Masquerading as Acute Pericarditis in a Young Cannabis User.

Aung Bhone Paing, Taha Elsahy, Abdullah Shaik, Dhruv Kundu, Maheen Iqbal

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aung Bhone PaingAcute Medicine, Peterborough City Hospital, Peterborough, GBR.
Taha ElsahyAcute Medicine, Peterborough City Hospital, Peterborough, GBR.
Abdullah ShaikAcute Medicine, Peterborough City Hospital, Peterborough, GBR.
Dhruv KunduGeneral Medicine, Peterborough City Hospital, Peterborough, GBR.
Maheen IqbalAcute Medicine, Peterborough City Hospital, Peterborough, GBR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spontaneous pneumomediastinum (SPM) is defined as the presence of free air within the mediastinum without an apparent precipitating cause such as trauma, invasive procedures, or oesophageal rupture. SPM is typically benign and self-limiting but may mimic life-threatening conditions such as myocardial infarction, pulmonary embolism, or aortic dissection. The pathophysiology is most explained by the Macklin effect, where increased intra-alveolar pressure leads to alveolar rupture and dissection of air along bronchovascular sheaths into the mediastinum. Recognized risk factors include intense physical exertion, vomiting, Valsalva manoeuvres, and recreational drug use such as cannabis and cocaine inhalation. Although SPM usually follows a benign course, prompt diagnosis is important to exclude secondary causes such as Boerhaave syndrome or tracheobronchial injury, which carry significant morbidity and mortality if missed. We report the case of a healthy 18-year-old male who developed extensive spontaneous pneumomediastinum shortly after smoking, with a background of prior cocaine use. This case highlights the importance of recognizing SPM in the differential diagnosis of acute chest pain in young adults and reinforces the value of conservative management following thorough exclusion of secondary causes.

Indexed as

cannabischest painpericarditispneumomediastinumsmokingtroponin

Identifiers

PMID41376758
PMCPMC12687917

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.