ArticleCureus2025
Asynchronous Bilateral Pneumothorax in a Patient With Birt-Hogg-Dubé Syndrome: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Birt-Hogg-Dubé (BHD) syndrome is a rare autosomal dominant genetic disorder caused by mutations in the Folliculin (FLCN) gene and characterized by cutaneous fibrofolliculomas, multiple pulmonary cysts, spontaneous pneumothorax, and renal tumours. Pulmonary involvement is frequent and may represent the earliest manifestation of BHD. Due to its variable presentation, diagnosis is often delayed or missed. We report the case of a 38-year-old woman with a known history of multiple sclerosis who presented with recurrent, asynchronous, bilateral, spontaneous pneumothoraces over a 15-month period, including during pregnancy. Imaging revealed bilateral apical lung air-filled cysts. Management included conservative treatment, chest tube insertion, and ultimately bilateral video-assisted thoracoscopic surgery (VATS) bullectomy and apical pleurectomy. During a multidisciplinary evaluation during pregnancy, numerous white to skin-coloured waxy papules were noticed, prompting a dermatologic consultation. The diagnosis of BHD syndrome was confirmed via skin biopsy. Family screening identified the same condition in her mother. Renal imaging showed no abnormalities, but long-term surveillance was advised. This case highlights the potential for misdiagnosis or delayed diagnosis of BHD syndrome in patients presenting with spontaneous pneumothorax. A detailed family history, early recognition, and multidisciplinary evaluation are essential for early and appropriate management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.