Spontaneous regression rate of high-grade cervical lesions in women under 35 at Dijon University Hospital: Incidence and predictive factors.

Introduction: According to current guidelines, women with CIN 2/3 should undergo a conization procedure. However, for young patients with small lesions, it is possible to consider therapeutic abstention with close monitoring while awaiting potential spontaneous regression. The objectives of this study were to evaluate the regression rate of CIN 2/3 lesions over 24 months of follow-up in women under the age of 35 and to identify predictive factors for spontaneous healing. Methods: This was a retrospective observational study based on data from patients diagnosed with CIN 2 or CIN 3 who underwent close monitoring every 6 months via colposcopy, for a maximum follow-up period of 24 months between May 2008 and May 2024. The primary endpoint was the rate of spontaneous regression of high-grade lesions. Results: 104 patients, with a mean age of 27.8 years, were included. Cervical intraepithelial neoplasia spontaneously regressed in 37 patients (35.6 %, Conclusion: The results of the study are consistent with the literature and support the possibility of 24-month surveillance of patients with a high-grade lesion, especially given the low risk of progression to more severe disease within two years.