Evidence map›Paper›PMID 41376713›Full record

ArticleAddiction neuroscience2025

Adolescent social isolation associated changes in ethanol-induced dopamine regulation in the ventral pallidum.

Gavin J Vaughan, Makenzie R Lehr, Gina M Magardino, Abigail M Kelley, Michelle A Chan, Madison C Heitkamp, Jordan T Yorgason, Anushree N Karkhanis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Addiction neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gavin J VaughanDepartment of Psychology, Developmental Exposure to Alcohol Research Center, Center for Developmental and Behavioral Neuroscience, Binghamton University - The State University of New York, Binghamton, NY, USA.
Makenzie R LehrDepartment of Psychology, Developmental Exposure to Alcohol Research Center, Center for Developmental and Behavioral Neuroscience, Binghamton University - The State University of New York, Binghamton, NY, USA.
Gina M MagardinoDepartment of Psychology, Developmental Exposure to Alcohol Research Center, Center for Developmental and Behavioral Neuroscience, Binghamton University - The State University of New York, Binghamton, NY, USA.
Abigail M KelleyDepartment of Psychology, Developmental Exposure to Alcohol Research Center, Center for Developmental and Behavioral Neuroscience, Binghamton University - The State University of New York, Binghamton, NY, USA.
Michelle A ChanDepartment of Psychology, Developmental Exposure to Alcohol Research Center, Center for Developmental and Behavioral Neuroscience, Binghamton University - The State University of New York, Binghamton, NY, USA.
Madison C HeitkampDepartment of Psychology, Developmental Exposure to Alcohol Research Center, Center for Developmental and Behavioral Neuroscience, Binghamton University - The State University of New York, Binghamton, NY, USA.
Jordan T YorgasonDepartment of Cell Biology and Physiology, Brigham Young University, Provo, UT, USA.
Anushree N KarkhanisDepartment of Psychology, Developmental Exposure to Alcohol Research Center, Center for Developmental and Behavioral Neuroscience, Binghamton University - The State University of New York, Binghamton, NY, USA.ORCID 0000-0002-8271-3500

Funding

Development and Neuroadaptations in Alcohol and Addictions (DNA2)T32AA025606 · NIAAA · STATE UNIVERSITY OF NY,BINGHAMTON · PI J. DAVID JENTSCH · 2017 to 2026
$2.7M
Mechanisms of rostrocaudal differences in accumbal kappa opioid receptor effects on ethanol drinkingR01AA028228 · NIAAA · STATE UNIVERSITY OF NY,BINGHAMTON · PI BARSON, JESSICA ROSE, KARKHANIS, ANUSHREE N · 2021 to 2025
$2.5M
Neuroimmune mechanisms of alcohol rewardR01AA030577 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jordan Thomas Yorgason · 2023 to 2026
$1.3M
Impact of early life stress on accumbal kappa opioid signaling and ethanol intakeK01AA023874 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KARKHANIS, ANUSHREE N · 2016 to 2020
$673k
NIAAA NIH HHS K01 AA023874NIAAA NIH HHS R01 AA028228NIAAA NIH HHS R01 AA030577NIAAA NIH HHS T32 AA025606
6 · The paper itself

Abstract

Adolescent social isolation (aSI) has been demonstrated to increase anxiety-like behavior and ethanol consumption. The ventral pallidum (VP), a basal ganglia structure that receives dopaminergic projections from the VTA, contributes to reward and aversion processing, and is highly responsive to psychosocial stressors. In our study, we sought to characterize the effects of aSI on maladaptive behavioral phenotypes such as anxiety-like behavior, ethanol consumption, and aversion-resistant ethanol-intake as measured by the consumption of ethanol (20 %, v/v) adulterated with the bitterant quinine (0, 3, 10, 30, 100 mg/l). We further used

Indexed as

Adolescent stressDopamineEthanolVentral pallidum

Identifiers

PMID41376713
PMCPMC12687745

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.