Trial reportDrug design, development and therapy2025
The Effect of Pericapsular Nerve Group Block with Liposomal Bupivacaine on Postoperative Rebound Pain in Older Hip Fracture Patients: A Randomized Controlled Trial.
Trial report in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Anterior Quadratus Lumborum Block with Liposomal Bupivacaine versus Ropivacaine for Postoperative Recovery in Laparoscopic Colorectal Surgery: A Randomized Controlled Trial.Drug design, development and therapy · 2026Trial
- Reappraising the fascia iliaca compartment block and pericapsular nerve group block for geriatric hip fractures: a narrative review.Journal of anesthesia, analgesia and critical care · 2026Review
- Rebound pain following peripheral nerve block in extremity fracture surgery: pathophysiological mechanisms based on the "Triple-Hit" model and multimodal preventive strategies.Frontiers in medicine · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aims to investigate and discuss the effect of pericapsular nerve group (PENG) block with liposomal bupivacaine (LB) on postoperative rebound pain following hip fracture in older adults. Patients and Methods: Ninety patients scheduled for hip fracture surgery were randomized into three groups: LB (liposomal bupivacaine, 30 mL), R (0.375% ropivacaine, 30 mL), and C (saline, 30 mL). MAP and HR were recorded at T1 (pre-induction), T2 (post-intervention), and T3 (skin incision). NRS scores were evaluated at 12-72 h postoperatively, along with rebound pain, quadriceps function, analgesic consumption, and adverse reactions. Results: The incidence of rebound pain was significantly lower in the LB and R groups than in the C group (p < 0.05). The AUC of NRS scores over 72 hours was significantly lower in the LB group (2.053 ± 1.258) than in the R (3.600 ± 2.087) and C (4.880 ± 2.739) groups (p < 0.0001). Hemodynamic analysis revealed significant differences in HR between T2 and T3 in all groups (LB: 77.10 ± 11.28 vs 73.77 ± 8.47; R: 79.57 ± 8.05 vs 74.00 ± 8.13; C: 80.50 ± 8.71 vs 84.13 ± 8.07; p < 0.05). MAP in the LB group differed significantly from Group C across the three time points (p < 0.05). There were no significant differences between the groups in adverse events. Conclusion: LB PENG blockade reduces rebound pain incidence post-nerve block in elderly hip fracture patients, decreases PCA demand, preserves quadriceps function, and enhances satisfaction.
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