ReviewBiochemistry and biophysics reports2026
Unlocking the potential of endophytes in enhancing plant secondary metabolite biosynthesis.
Review in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Unlocking the hidden potential of the genus Salvia through a systematic review of endophytic bacterial and fungal diversity and biotechnological prospects.Archives of microbiology · 2026Pooled it
- Endophyte function in climate-stressed crops: integrating molecular regulation, metabolic trade-offs, and ecological constraints.Plant signaling & behavior · 2026Review
- Harnessing Endophytic Fungi as a Sustainable Source of Novel Anticancer Agents: Opportunities, Challenges, and Future Directions.Molecules (Basel, Switzerland) · 2026Review
- A comprehensive review on bacterial endophytic secondary metabolites: a road map from crude extract to lead molecule production.Frontiers in pharmacology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant secondary metabolites (PSMs) are vital bioactive compounds with wide pharmaceutical, agricultural, and industrial applications. However, their commercial production faces challenges due to low yields, environmental variability, and high extraction costs. Endophytes, microorganisms living within plant tissues, have emerged as key regulators of plant metabolism, enhancing PSM production through activation of biosynthetic gene clusters, secretion of precursor molecules, and modulation of plant stress responses. This narrative review explores recent advances in understanding endophyte-plant interactions, focusing on their mechanisms for stimulating metabolite production. It highlights biotechnological applications, including metabolic engineering, genome editing, and co-cultivation strategies, for optimizing endophyte-mediated biosynthesis. The review also identifies challenges in large-scale application and proposes recommendations for integrating endophytes into sustainable agriculture and pharmaceutical production. Harnessing endophytes offers an eco-friendly, cost-effective approach for scalable natural product biosynthesis, with significant potential for addressing global health, agricultural sustainability, and industrial needs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.