ArticleJournal of the Endocrine Society2026
Thermogenic Gene Expression in Human Neck Adipose Tissue in Relation to Circulating and Local Thyroid Hormone Levels.
Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Thermogenic Gene Expression in Human Neck Adipose Tissue in Relation to Circulating and Local Thyroid Hormone Levels.Journal of the Endocrine Society · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Introduction: Brown adipose tissue (BAT) contributes to thermogenesis and has been proposed as a therapeutic target for metabolic disease. Thyroid hormones (THs) regulate thermogenic activity, but the relationship between circulating and local TH concentrations and their associations with thermogenic gene and pathway expression in human adipose tissue remain unclear. Methods: We obtained paired deep neck and subcutaneous adipose tissue samples from adults undergoing thyroid surgery, which represent BAT and white adipose tissue, respectively. Serum and local adipose tissue TH concentrations (T3, T4, TSH) were measured. Bulk RNA-sequencing was performed on adipose tissue samples. Associations between hormone concentrations and thermogenic gene expression and pathway activation were analyzed, with false discovery rate correction for multiple testing. Results: Both serum and local T4 concentrations were positively associated with thermogenic pathway activation in deep neck adipose tissue. Although serum T3 was also positively associated, local T3 was inversely associated with thermogenic pathways in deep neck adipose tissue. However, circulating TH concentrations did not correlate with local tissue hormone levels. No significant associations were observed between serum or local TH concentrations and individual thermogenic gene expression after correction for different clinical covariates and multiple comparisons. Conclusion: Local regulation of THs may play a role in human adipose tissue thermogenic activity. Pathway-level transcriptomic analysis may better capture these effects than single-gene approaches. Deep neck adipose tissue can serve as a practical model for studying BAT function and endocrine regulation in humans.
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Registered trials
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