ArticleJournal of the Endocrine Society2026
Skeletal Microstructure in Addison's Disease.
Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Context: Addison's disease (AD) is characterized by deficient adrenal glucocorticoid (GC) production. Treatment involves just GC replacement, but patients often receive high doses, leading to side effects. Bone mineral density (BMD) data in AD are conflicting. High-resolution peripheral quantitative computed tomography (HRpQCT) evaluates volumetric BMD, microarchitecture, and mechanical properties of the tibia and radius. No studies have assessed bone quality by HRpQCT on subjects with AD. Objective: Evaluate the bone health of patients with AD using HRpQCT. Design: Cross-sectional study. Setting: Ambulatory of a tertiary medical center. Participants: Nineteen patients with AD on GC were compared to 38 matched controls. Main Outcome Measures: Dual-energy x-ray absorptiometry and HRpQCT measurements. Results: Patients with AD had lower lean mass and BMD. At the radius, the AD group had 11% lower trabecular (Tb) number ( Conclusion: This is the first study to assess bone using HRpQCT in patients with AD on GC. Our findings suggest that AD patients have a loss of lean mass and skeletal fragility, mainly of the trabecular compartment and at the tibia. Bone loss may be related to loss of lean mass and GC.
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