ReviewFrontiers in immunology2025
Podocyte, tubular epithelial-immune cell interplay in the pathogenesis of lupus nephritis.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Renal Tubular Epithelial Cells as Central Hubs of Kidney Disease.Diagnostics (Basel, Switzerland) · 2026Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lupus nephritis (LN), a severe complication of systemic lupus erythematosus (SLE), is associated with increased morbidity and mortality. The pathogenesis of LN involves complex immune-mediated mechanisms that alter the biology of renal resident epithelial cells. Emerging evidence highlights the bidirectional interactions between immune cells and renal epithelial cells-including podocytes and tubular epithelial cells(TECs)-as critical contributors to disease progression. These interactions shape local immune responses, drive inflammatory injury, and disrupt renal function. However, the molecular and cellular basis of this crosstalk remains incompletely understood. Recent advances have uncovered key mechanisms underlying these interactions and identified potential therapeutic targets that may inform future treatment strategies. This review summarizes current findings on the immunological roles of renal epithelial cells in LN and discusses their relevance to the development of targeted and cell-specific therapeutic interventions.
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Registered trials
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