Evidence map›Paper›PMID 41376599›Full record

ArticleDrug delivery2025

Photosensitive composite nanoparticles adsorbing p-sh

Xuelian Luo, Xiaohan Wu, Haifeng Ai, Chunrong Li, Hanghang Jiang, Conghui Wang, Jielin Liu, Song Xiao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xuelian LuoDepartment of Immunology, School of Basic Medicine, Guizhou Medical University, Guiyang, China.
Xiaohan WuDepartment of Immunology, School of Basic Medicine, Guizhou Medical University, Guiyang, China.
Haifeng AiDepartment of Immunology, School of Basic Medicine, Guizhou Medical University, Guiyang, China.
Chunrong LiTechnology Research and Development Center, Qiannan Medical College for Nationalities, Duyun, China.
Hanghang JiangDepartment of Immunology, School of Basic Medicine, Guizhou Medical University, Guiyang, China.
Conghui WangDepartment of Immunology, School of Basic Medicine, Guizhou Medical University, Guiyang, China.
Jielin LiuDepartment of Immunology, School of Basic Medicine, Guizhou Medical University, Guiyang, China.
Song XiaoDepartment of Immunology, School of Basic Medicine, Guizhou Medical University, Guiyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photodynamic therapy (PDT) represents a promising noninvasive modality for the selective targeting of tumors. However, its clinical utility is often constrained by the aggregation-induced quenching of photosensitizers and suboptimal reactive oxygen species (ROS) generation. In contrast, gene therapy has exhibited potent antitumor efficacy through the specific silencing of oncogenic targets. In this study, we developed a cationic photosensitizer-based nanocarrier, PEI-PEG-PpIX, designed to deliver the shRNA-

Indexed as

NanoparticlesNeuroblastomaPhotochemotherapyPhotosensitizing AgentsRNA, Small InterferingAnimalsCell Line, TumorCell ProliferationFemaleGenetic TherapyHumansMiceMice, Inbred BALB CMice, NudePlasmidsPolyethylene GlycolsPhotosensitizing AgentsPolyethylene GlycolsPolyethyleneimineReactive Oxygen SpeciesRNA, Small Interferingcombination therapygene therapynanocarrierPhotodynamic therapyphotosensitizer

Identifiers

PMID41376599
PMCPMC12716475

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.