Evidence map›Paper›PMID 41376597›Full record

ReviewHippocampus2026

Sex Differences in the Ventral Subiculum's Microcircuitry and Function.

C N Miller, J Aoto

Abstract readReview
In one paragraph

Review in Hippocampus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Mapping Projectome Heterogeneity of Subiculum Neuron Cell Types.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Hippocampome.org, a resource for subicular neuron types and beyond.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

C N MillerDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID 0000-0002-8746-7206
J AotoDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID 0000-0003-0568-634X

Funding

Functional and mechanistic interrogation of alpha neurexin extracellular domainsR01MH116901 · NIMH · UNIVERSITY OF COLORADO DENVER · PI AOTO, JASON · 2018 to 2022
$1.9M
Predoctoral Training Grant in Pharmacology and Molecular MedicineT32GM158468 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Jason Aoto, James Christopher Costello · 2025 to 2026
$685k
The identification and interrogation of novel intracellular proteins that underlie the distinct nanoscopic architecture of Neurexin-1 and Neurexin-3R21MH140328 · NIMH · UNIVERSITY OF COLORADO DENVER · PI AOTO, JASON · 2025 to 2025
$422k
Control of subsynaptic domain organization and nanocolumn alignment by neurexin-3R21MH129620 · NIMH · UNIVERSITY OF COLORADO DENVER · PI AOTO, JASON · 2022 to 2023
$408k
Impact of stress on heroin seeking and ventral pallidal synapse functionF30DA057053 · NIDA · UNIVERSITY OF COLORADO DENVER · PI MILLER, CARLEY N · 2022 to 2024
$117k
NIDA NIH HHS F30DA057053NIGMS NIH HHS 5T32GM007635NIGMS NIH HHS 5T32GM008497NIGMS NIH HHS T32 GM158468NIMH NIH HHS R01 MH116901NIMH NIH HHS R01MH116901NIMH NIH HHS R21MH129620NIMH NIH HHS R21MH140328
6 · The paper itself

Abstract

The ventral subiculum has long been appreciated as the major output structure of the ventral hippocampus but remains greatly understudied relative to the other hippocampal subregions. Over the last decade, investigation into ventral subiculum synapses and connectivity has revealed a critical role for this brain region in context-induced drug seeking, stress integration, and psychiatric disorders. While the majority of literature has historically focused on male rodent models, recent works including sex as a biological variable uncover that the ventral subiculum may have complex cell-type-, synapse-, and sex-specific roles in its functions. In this review, we discuss the primary functions of the ventral subiculum, emphasize works that uncover sex differences, and highlight avenues for future research.

Indexed as

HippocampusNerve NetSex CharacteristicsAnimalsFemaleHumansMaleSynapsesinterneuronsphysiological stresspyramidal cellssex differencessubiculumsubstance use disordersynapses

Identifiers

PMID41376597
PMCPMC12915510

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.