Evidence map›Paper›PMID 41376586›Full record

ArticleHypertension (Dallas, Tex. : 1979)2026

Affective Responsivity and Cardiovascular Stress Reactivity in Depression.

Ashley M Darling, Cynthia M Dominguez, Jacqueline Mogle, Paul J Fadel, Erika F H Saunders, David M Almeida, Jody L Greaney

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ashley M DarlingDepartment of Kinesiology (A.M.D., P.J.F., J.L.G.), The University of Texas at Arlington, TX.
Cynthia M DominguezDepartment of Bioengineering (C.M.D.), The University of Texas at Arlington, TX.ORCID 0009-0003-0456-7637
Jacqueline MogleRTI Health Solutions, Durham, NC (J.M.).
Paul J FadelDepartment of Kinesiology (A.M.D., P.J.F., J.L.G.), The University of Texas at Arlington, TX.ORCID 0000-0002-0115-0743
Erika F H SaundersDepartment of Psychiatry and Behavioral Health, Penn State College of Medicine, Hershey, PA (E.F.H.S., J.L.G.).ORCID 0000-0001-7222-0828
David M AlmeidaDepartment of Human Development and Family Studies (D.M.A.), The Pennsylvania State University, University Park, PA.ORCID 0000-0002-5233-8148
Jody L GreaneyDepartment of Kinesiology (A.M.D., P.J.F., J.L.G.), The University of Texas at Arlington, TX.ORCID 0000-0002-9855-3978

Funding

Peripheral and Central Mechanisms of Neurovascular Dysfunction in Human DepressionR00HL133414 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI GREANEY, JODY · 2019 to 2021
$746k
Daily stress processes and sympathetic reactivity in depressionR21MH123928 · NIMH · UNIVERSITY OF TEXAS ARLINGTON · PI GREANEY, JODY · 2021 to 2022
$521k
Peripheral and Central Mechanisms of Neurovascular Dysfunction in Human DepressionK99HL133414 · NHLBI · PENNSYLVANIA STATE UNIVERSITY, THE · PI GREANEY, JODY · 2017 to 2018
$209k
NHLBI NIH HHS K99 HL133414NHLBI NIH HHS R00 HL133414NIMH NIH HHS R21 MH123928
6 · The paper itself

Abstract

backgroundProfound stress system dysfunction is a hallmark pathological feature of major depressive disorder (MDD), including altered affective dynamics in response to stress. However, no studies have directly assessed the link between negative affective responsivity (NA-R) to daily stressors and sympathetic-cardiovascular stress reactivity in young adults with MDD. We tested the hypotheses that (1) greater NA-R to daily stressors would be positively related to the magnitude of acute stress-induced sympathetic-cardiovascular reactivity in young adults (18-30 years) and (2) the slope of these relations would be steeper in young adults with MDD (unmedicated) compared with nondepressed healthy adults.

methodsDaily stress processes and affective dynamics were assessed during routine everyday life for 8 consecutive days in 42 nondepressed healthy adults and 39 adults with MDD (daily diary). On the last day of the daily assessments, heart rate (ECG), beat-to-beat blood pressure (finger photoplethysmography), and muscle sympathetic nerve activity (peroneal microneurography) were measured during the cold pressor test, a standard laboratory stressor.

resultsNA-R to daily stressors was amplified in MDD adults (

conclusionsThese data suggest that the association between NA-R to daily stressors and cardiovascular reactivity to stress is sensitized in young adults with MDD, potentially contributing to future cardiovascular disease risk.

Indexed as

AffectCardiovascular SystemHeart RateMajor Depressive DisorderStress, PsychologicalSympathetic Nervous SystemAdolescentAdultBlood PressureElectrocardiographyFemaleHumansMalePhotoplethysmographyYoung Adultblood pressurecardiovascular diseasesdepressive disorder, majorheart rateyoung adult

Identifiers

PMID41376586
PMCPMC12887601

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.