ArticleJournal of the American Chemical Society2026
Design of Phosphine-Heteroarenesulfonamide Ligands as Dinuclear Silver Catalysts for Enantioselective Construction of α,β-Diamino Acids.
Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Chiral Spiro-Scaffolded C(spAngewandte Chemie (International ed. in English) · 2026Article
- Asymmetric Iron-Catalyzed Vicinal C(spAngewandte Chemie (International ed. in English) · 2026Article
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Authors and funding
7 authors.
Funding
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Abstract
We designed and developed a phosphine-heteroarenesulfonamide ligand and found that it functions as a chiral dinuclear silver catalyst capable of cooperatively activating both nucleophiles and electrophiles. As a result, a highly enantioselective Mannich-type reaction between glycinate Schiff bases and acyclic ketiminoesters, unattainable by mononuclear catalytic systems, was achieved, affording α,β-diamino acid derivatives bearing tetrasubstituted chiral carbon centers in excellent yields and enantioselectivities. The resulting α,β-diamino acid derivatives were readily transformed into optically active 2-imidazolidinone and a dipeptide. Comprehensive mechanistic studies combining global reaction route mapping (GRRM), artificial force-induced reaction (AFIR), and density functional theory calculations revealed a cooperative bimetallic transition-state architecture responsible for the observed stereocontrol. These findings establish a new design principle for asymmetric catalysis based on homodinuclear activation and highlight the potential of dinuclear silver catalysis for the construction of complex chiral molecules.
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