Evidence map›Paper›PMID 41376230›Full record

Trial reportJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025

Efficacy and safety of Shi's cervical manipulation versus diclofenac for patients with acute and subacute neck pain: a multicenter clinical randomized trial.

Zhang Mingcai, Lin Xun, D U Guoqing, Liu Congying, Yuan Weian, L I Wei, Yang Jiayu, Chen Bo, Y U Xiaoyue, Xiong Yizhe and 7 more

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Zhang MingcaiShi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Lin XunCollege of International Education of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
D U GuoqingShi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Liu CongyingScience and Technology Center of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Yuan WeianShi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
L I WeiTraumatology & Orthopedics Department of Jing'an District Central Hospital of Shanghai, Shanghai 200040, China.
Yang JiayuTraumatology & Orthopedics Department of Xiangshan Hospital of Traditional Chinese Medicine, Shanghai 200001, China.
Chen BoShi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Y U XiaoyueTraumatology & Orthopedics Department of Jing'an District Central Hospital of Shanghai, Shanghai 200040, China.
Xiong YizheShi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Jiang EnyuTraumatology & Orthopedics Department of Xiangshan Hospital of Traditional Chinese Medicine, Shanghai 200001, China.
Gao NingyangShi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Jiang SuminTraumatology & Orthopedics Department of Jing'an District Central Hospital of Shanghai, Shanghai 200040, China.
X U ZhenqiuShi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Wang XiangShi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Zhan HongshengShi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
W U YufengTraumatology & Orthopedics Department of Zhongshan Hospital Affiliated to Guangzhou University of Traditional Chinese Medicine, Zhongshan 528401, China.

Funding

Biomechanical Mechanism of Tendon Off-position and Joint Subluxation and Manual Treatment for Adolescent Neck Pain 82374467Mechanism of Huaizhen Nourishing the Liver Capsule to Maintain the Balance of Knee Joint from the Coupling and Interaction of Skeletal Muscle-subchondral Bone Dynamics Rresponse 81704103Research on the Mechanism of Manipulation to Regulate Internalizing Integrin and its Downstream Focal Adhesion Kinase/Ras Homolog Gene Family Member A/Rho-associated Coiled-coil Containing Protein Kinase 1 Signaling Pathway to Repair Chronic Skeletal Muscle Injury 82374481
6 · The paper itself

Abstract

objectiveTo confirm the effectiveness and safety of Shi's manipulation in treating acute and subacute neck pain patients.

methodsThis multicenter, positive controlled, randomized clinical trial has trial and control groups. There were 240 patients randomly assigned to the trial group and the control group, and both groups received their respective intervention treatment methods for a period of 12 weeks. The time windows for clinical data collection were before treatment, immediately after treatment, 3-d 1, 2, 4, 8, and 12 -week after treatment, and follow-up was conducted at 26 and 52-week after treatment. The observed indicators used include primary outcome index and secondary outcome index, with the primary outcome index being the assessment of neck pain severity, which is evaluated by patients using Numerical Rating Scale (NRS). Secondary secondary outcome index include, (a) cervical dysfunction index, measured by patients using the Neck Disability Index (NDI) for self-assessment; (b) Cervical activity measurement, measured through the cervical range of motion measurement program on Android mobile system; (c) Satisfaction treatment assessment, determined by the patient's self-evaluation; (d) Safety index, recorded the incidence of adverse reactions and adverse event.

resultsThe results showed that these efficacy indices were improved in different degrees in both groups. At immediate after intervention, there was significant difference in NRS, NDI, Cervical Range of Motion (ROM) between the two groups (

conclusionOur findings suggest that Shi's manipulation can be a good complementary treatment option in patients with acute and subacute neck pain.

Indexed as

DiclofenacNeck PainAdultAgedFemaleHumansMaleMiddle AgedTreatment OutcomeYoung AdultDiclofenacdiclofenac sodium sustained-release capsulesneck painsafetyShi’s cervical manipulationtreatment outcome

Identifiers

PMID41376230
PMCPMC12703844

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.