Evidence map›Paper›PMID 41376229›Full record

Trial reportJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025

Traditional Chinese Medicine treatment with syndrome differentiation for patients with severe community-acquired pneumonia: a multicenter, randomized, placebo-controlled trial.

L I Jiansheng, Wang Haifeng, Zhang Kang, Xie Kai, L I Suyun, Zhang Chenxi, Zhang Yaqing

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

L I JianshengDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China.
Wang HaifengDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China.
Zhang KangDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China.
Xie KaiDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China.
L I SuyunDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China.
Zhang ChenxiCo-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of China, Henan University of Chinese Medicine, Zhengzhou 450046, China.
Zhang YaqingIntensive Care Unit, Zhengzhou 15th People's Hospital, Zhengzhou 450000, China.

Funding

a Randomized Controlled Trial STG-ZYX02-202204Mechanism of Qingre jiedu Huatan Formula Regulating Macrophage Mitochondrial Autophagy / NLR family pyrin domain containing 3 Inflammasome Activation and Intervening intestinal-Lung Bacterial Translocation in the Treatment of Severe Pneumonia 82074411Prevention and Treatment of Respiratory Critical Illness with Traditional Chinese Medicine 22IRTSTHN029
6 · The paper itself

Abstract

objectiveTo assess the effect of Traditional Chinese Medicine (TCM) treatment with syndrome differentiation in patients with severe community-acquired pneumonia (CAP).

methodsA multicenter, randomized, placebo-controlled trial was conducted. Adult patients with severe CAP were randomly allocated to receive conventional medicine treatment (conventional group) or conventional medicine combine with TCM treatment with syndrome differentiation (combination group) underwent a 28-d treatment time. The primary endpoint was treatment failure. Secondary outcomes included time to clinical stability, 28-d mortality, 90-d mortality, length of hospital stay.

resultsA total of 183 patients were included in the intention-to-treat (ITT) population, with 91 allocated to the combination group and 92 to the conventional group. Patients with treatment failure in the combination group (18/91, 19.8%) were lower compared with the conventional group (34/92, 37.0%). Time to clinical stability was shorter in the combination group (11.8 d) than in the conventional group [17.8 d;

conclusionAmong patients with severe CAP, TCM treatment with syndrome differentiation reduced treatment failure, time to clinical stability, and the 28-d mortality and the 90-d mortality among patients admitted to the ward, without an increase in complications.

Indexed as

Community-Acquired PneumoniaDrugs, Chinese HerbalAdultAgedAged, 80 and overCommunity-Acquired InfectionsFemaleHumansMaleMedicine, Chinese TraditionalMiddle AgedPneumoniaTreatment OutcomeDrugs, Chinese Herbalcommunity-acquired pneumoniamedicine, Chinese traditionalrandomized controlled trialtreatment failuretreatment with syndrome differentiation

Identifiers

PMID41376229
PMCPMC12712292

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.