Evidence map›Paper›PMID 41376228›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025

Exploration of the mechanism of the Mongolian medicine Tonglaga-5 (-5) for the treatment of n-methyl-n'-nitro-n-nitrosoguanidine-induced chronic atrophic gastritis based on network pharmacology and metabolomics.

Cheng Ziqi, Dong Xin, Temuribagen, X U Caimeng, H U Shaonan, Chen Qianwen, Wang Yuewu, Wang Haibo, H E Xiaoyu, Xue Dan and 1 more

Abstract read
In one paragraph

Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cheng ZiqiDepartment of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China.
Dong XinDepartment of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China.
TemuribagenDepartment of Orthopedic, Hohhot city Mongolian medicine Hospital of Traditional Chinese Medicine, Hohhot 010110, China.
X U CaimengDepartment of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China.
H U ShaonanDepartment of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China.
Chen QianwenDepartment of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China.
Wang YuewuDepartment of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China.
Wang HaiboDepartment of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China.
H E XiaoyuDepartment of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China.
Xue DanDepartment of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China.
Xue PeifengDepartment of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China.

Funding

Grassland Talent Rolling Support Program [2023]3New Quality Control Model of Mongolian Medicine Tonglaga-5 "Qingzhuo Shenghua" Based on "Stomach Blood Bone Correlation Tracking" 82160745Preparation and Pharmacological Study of Mongolian Medicine Tonglaga-5 Transdermal Patch MYYXTPY202313Research on the Mechanism of Mongolian Prescription Tonglaga-5 in Treating Chronic Atrophic Gastritis based on Multiomics Integration YKD2024ZD001
6 · The paper itself

Abstract

objectiveTo explore the mechanism of Tonglaga-5 (-5, TLG-5) for the treatment of chronic atrophic gastritis (CAG), based on network pharmacology and metabolomics.

methodsForty-eight male Sprague-Dawley rats were randomly divided into six groups (

resultsHigh-dose TLG-5 significantly improved the expression of PG Ⅰ, PGR (PG Ⅰ/ PG Ⅱ) and G-17 (

conclusionsTLG-5 exerts a therapeutic effect on CAG by regulating β-alanine metabolism, pyrimidine metabolism pathways, and inhibiting the PI3K-AKT signaling pathway and HIF-1 signaling pathways.

Indexed as

Drugs, Chinese HerbalGastritis, AtrophicAnimalsChronic DiseaseGastrinsHumansHypoxia-Inducible Factor 1, alpha SubunitMaleMedicine, Mongolian TraditionalMetabolomicsNetwork PharmacologyPepsinogen AProto-Oncogene Proteins c-aktRatsRats, Sprague-DawleySignal TransductionDrugs, Chinese HerbalGastrinsHypoxia-Inducible Factor 1, alpha SubunitPepsinogen AProto-Oncogene Proteins c-aktgastritis, atrophicmetabolomicsnetwork pharm-acologyreal-time polymerase chain reactionTonglaga-5

Identifiers

PMID41376228
PMCPMC12711641

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.