Evidence map›Paper›PMID 41376221›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025

New approach to overcoming antimicrobial resistance of by combining Guanghuoxiang () and Penicillin G Sodium treatments.

Jing Wenguang, Wang Zhixia, P I Wenmin, W U Haonan, L I Minghua, Wang Penglong, Cheng Xianlong, Wei Feng

Abstract read
In one paragraph

Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jing WenguangNational Institutes for Food and Drug Control, Beijing 100050, China.
Wang ZhixiaSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 102488, China.
P I WenminSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 102488, China.
W U HaonanNational Institutes for Food and Drug Control, Beijing 100050, China.
L I MinghuaNational Institutes for Food and Drug Control, Beijing 100050, China.
Wang PenglongSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 102488, China.
Cheng XianlongNational Institutes for Food and Drug Control, Beijing 100050, China.
Wei FengNational Institutes for Food and Drug Control, Beijing 100050, China.

Funding

State Key Laboratory of Drug Regulatory Science, Establishment of a Comprehensive Evaluation Method for the Quality of Chinese Medicinal Herbs . and ., Suited to the Characteristics of Traditional Chinese Medicine 2023SKLDRS0101
6 · The paper itself

Abstract

objectiveAntibiotics are the main drugs used to treat bacterial infections, which have been extensively utilized across various fields. However, the problem of antimicrobial resistance (AMR) has greatly limited its use, leading to the creation of various superbugs such as Methicillin-resistant Staphylococcus aureus (MRSA), making antibiotics less effective, become a major global public health challenge. MRSA, which is resistant to most β-lactam and cephalosporin antibiotics, poses a significant threat to public health. Combination therapy has shown promise as a strategy to combat multi-drug-resistant bacteria. Chinese medicine also has potential applications in this field. Thus, we tried to find a new approach to overcoming MRSA by combining Chinese herb and penicillin G sodium (PGS).

methodsThe antibacterial activity of Guanghuoxiang (

resultsIn this study, we find that the Guanghuoxiang (

conclusionCombining Guanghuoxiang (

Indexed as

Anti-Bacterial AgentsDrugs, Chinese HerbalMethicillin-Resistant Staphylococcus aureusPenicillin GStaphylococcal InfectionsDrug SynergismHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsDrugs, Chinese HerbalPenicillin GCombination therapyGuanghuoxiang ()MRSAPenicillin G sodium

Identifiers

PMID41376221
PMCPMC12711633

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.