Evidence map›Paper›PMID 41376218›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025

Hypoglycemic mechanism of modified Gegen Qinlian decoction based on regulating the expression and DNA methylation of cholesterol transporters in the adipose tissue of type 2 diabetes mellitus rats.

Peng Shuhong, Yang Lingkun, Liu Xinyi, Zhang Mengyu, Lin Seqi, Zhang Changhua, X U Guoliang, Zhu Weifeng, Yao Pengcheng

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Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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9 authors.

Peng ShuhongResearch Center for Differentiation and Development of TCM Basic Theory, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Yang LingkunResearch Center for Differentiation and Development of TCM Basic Theory, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Liu XinyiResearch Center for Differentiation and Development of TCM Basic Theory, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Zhang MengyuResearch Center for Differentiation and Development of TCM Basic Theory, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Lin SeqiResearch Center for Differentiation and Development of TCM Basic Theory, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Zhang ChanghuaSchool of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
X U GuoliangResearch Center for Differentiation and Development of TCM Basic Theory, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Zhu WeifengState Key Laboratory of Modern Preparation of TCM, Ministry of Education, Nanchang 330004, China.
Yao PengchengResearch Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China.

Funding

Cause of "Dampness Stagnating in Pi" in Type 2 Diabetes Mellitus by Overeating High Fat and Sugar Diet Based on Glycerol Transport Which Is Affected by Methylation/Hormones Signal 82160830Investigation on the Mechanism of Gegen Qinlian Decoction in Lowering Blood Glucose Based on Improving Cholesterol Homeostasis of Lipid Rafts in Adipocytes 82060741Investigation on the Mechanism of Gegen Qinlian Decoction in Lowering Blood Glucose Based on Improving Phosphatidylcholine Biosynthesis in Adipose Tissue 82360799Jiangxi University of Chinese Medicine, First-level Discipline of Integrative Medicine (Jiangxi Province Double First-class Discipline) zxyylxk20220103Jiangxi University of Chinese Medicine Science and Technology Innovation Team Development Program CXTD22007Relationship between Adipose Tissue and Spleen Image Based on Multivariate Analysis of Modern Literature (No. 2020B0328). Ganpo Juncai-Training Program for Academic and Technical Leaders in Major Disciplines of the Province (Leading Talents-Academic Category) 20232BCJ22022
6 · The paper itself

Abstract

objectiveTo investigate the hypoglycemic mechanism of modified Gegen Qinlian decoction (，MGQD) by examining its regulation of cholesterol transporter expression and DNA methylation, specifically the low-density lipoprotein receptor (LDLR) and scavenger receptor class B type 1 (SR-B1), in epididymal white adipose tissue (eWAT) and inguinal white adipose tissue (iWAT) of rats with type 2 diabetes mellitus (T2DM).

methodsThe control group (CON) consisted of ten Sprague-Dawley (SD) rats fed a standard chow diet, while 80 SD rats were fed a high-fat diet and administered streptozotocin intraperitoneally to induce diabetes. The diabetic rats were randomly assigned to four groups: T2DM, metformin (MET, 200 mg/kg), low-dose MGQD (MGQDL, 5 g/kg), and high-dose MGQD (MGQDH, 10 g/kg), and received treatment

resultsMGQD and metformin treatment significantly reduced blood glucose levels, restored LDLR and SR-B1 protein levels in eWAT, and effectively regulated the mRNA expression and non-cytosine-p-guanine (non-CpG) methylation of

conclusionsMGQD did not significantly affect LDLR and SR-B1 expression or gene methylation in iWAT. However, its hypoglycemic effect may be linked to cholesterol regulation in eWAT. Potential mechanisms include increased LDLR protein levels, which may enhance cholesterol uptake, and increased

Indexed as

Adipose TissueCholesterolDiabetes Mellitus, Type 2DNA MethylationDrugs, Chinese HerbalHypoglycemic AgentsAnimalsHumansMaleRatsRats, Sprague-DawleyReceptors, LDLScavenger Receptors, Class BCholesterolDrugs, Chinese HerbalgegenqinlianHypoglycemic AgentsReceptors, LDLScavenger Receptors, Class Badipose tissuecholesterol transporterdiabetes mellitus, type 2DNA methylationmodified Gegen Qinlian decoctionreceptors, LDLscavenger receptors, class B

Identifiers

PMID41376218
PMCPMC12711643

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.