SynthesisInternal medicine journal2026
Alcohol consumption and risk of dementia: a systematic review and meta-analysis.
Synthesis in Internal medicine journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Associations of alcohol use in early and middle adulthood with mid- and late-life cognition - a synthetic cohort approach.medRxiv : the preprint server for health sciences · 2026Article
- Prevention of cognitive decline and dementia: Current evidence on lifestyle factors and dietary patterns.EXCLI journal · 2026Review
- Artificial intelligence and machine learning for precision prevention of cognitive decline: integrating multimodal biomarkers, lifestyle interventions, and natural medicines from prediction to clinical practice.Frontiers in aging neuroscience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
To examine the relationship between alcohol intake and the risk of developing dementia, we conducted a comprehensive search of PubMed, Embase, Cochrane Library and Web of Science databases for relevant studies up to July 22, 2024. The quality of the original studies was appraised utilising the Newcastle-Ottawa Scale (NOS). The link between alcohol intake and the risk of dementia was presented using relative risks (RRs) and their corresponding 95% confidence intervals (CIs). Subgroup analyses were implemented based on the level of alcohol consumption, geographic region and age. All statistical analyses were executed utilising Stata 15.0. The meta-analysis unveiled no significant link between alcohol exposure and the risk of developing dementia, including all-cause dementia (ACD) (RR = 1.03, 95% CI: 0.84-1.27), Alzheimer disease (AD) (RR = 0.97, 95% CI: 0.86-1.08), vascular dementia (VD) (RR = 1.09, 95% CI: 0.95-1.26) and other dementia (RR = 0.62, 95% CI: 0.33-1.15). In the subgroup analysis by drinking levels, light to moderate alcohol intake was linked to a decreased risk of ACD and AD (RR = 0.88, 95% CI: 0.81-0.96; RR = 0.88, 95% CI: 0.79-0.97, respectively). Nonetheless, heavy alcohol consumption significantly increased the risk of developing all types of dementia (ACD, RR = 1.18, 95% CI: 1.02-1.36; AD, RR = 1.29, 95% CI: 1.21-1.36; VD, RR = 1.25, 95% CI: 1.11-1.40). Further subgroup analyses indicated that light to moderate drinking's protective effect was stronger in Europe and among individuals aged 60 to 69 years. Light to moderate drinking may protect against dementia, while heavy drinking or alcohol use disorders raises dementia risk.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.