Evidence map›Paper›PMID 41376060›Full record

ReviewFoods (Basel, Switzerland)2025

Current Status and Future Perspectives of Betaine and Betaine-Based Natural Deep Eutectic Solvents: A Review.

Aylin Allahyari, Maryam Borji, Ali Jahanban-Esfahlan, Ali Khanalipour, Mahnaz Tabibiazar, Parisa Ahmadi

Abstract readReview
In one paragraph

Review in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Green Extraction of Phenolic Compounds from Blueberry (Antioxidants (Basel, Switzerland) · 2026
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aylin AllahyariDepartment of Food Science and Technology, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz 5165665811, Iran.
Maryam BorjiDepartment of Food Science and Technology, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz 5165665811, Iran.
Ali Jahanban-EsfahlanBiotechnology Research Center, Tabriz University of Medical Sciences, Tabriz 5165665813, Iran.ORCID 0000-0001-8693-3837
Ali KhanalipourDepartment of Food Science and Technology, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz 5165665811, Iran.
Mahnaz TabibiazarDepartment of Food Science and Technology, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz 5165665811, Iran.ORCID 0000-0002-9285-3187
Parisa AhmadiDepartment of Food Science and Technology, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz 5165665811, Iran.

Funding

Tabriz University of Medical Sciences 75659
6 · The paper itself

Abstract

Betaine (BET)-based deep eutectic solvents (DESs) have emerged as promising substitutes for traditional organic solvents owing to their eco-friendly properties and versatility in various applications. This review provides a comprehensive overview of the current status and future perspectives of BET-based DESs, highlighting their definition, characteristics, and mechanisms of eutectic formation. The unique properties of BET, including its biodegradability and non-toxicity, make it an attractive hydrogen bond acceptor in the formulation of DESs. The review discusses common methods for preparing BET-based DESs and emphasizes their applications in extraction processes, catalysis, biocompatibility, and pharmaceutical applications. Additionally, challenges such as stability and fluidity limitations are addressed, along with regulatory and safety considerations. Future directions suggest an increasing industrial application of BET-based DESs in environmentally sustainable processes within the food and pharmaceutical sectors, underlining their potential as green solvents in next-generation chemical methodologies.

Indexed as

BETfood industrynatural deep eutectic solventspharmaceuticals

Identifiers

PMID41376060
PMCPMC12692387

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.