Evidence map›Paper›PMID 41375713›Full record

ReviewJournal of clinical medicine2025

Ophthalmologic Comorbidities in Alopecia Areata.

Piedad M Guavita Falla, Diego Buendía-Castaño, Ángela Hermosa-Gelbard, Bárbara Burgos-Blasco, Patricia Burgos-Blasco, Sergio Vañó-Galván, David Saceda-Corralo

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Piedad M Guavita FallaDermatology Service, Pedro de Valdivia RedSalud Medical Center, Av. Nueva Providencia 1920, Metropolitan Area, Providencia 7500000, Chile.ORCID 0000-0002-7650-0875
Diego Buendía-CastañoDermatology Department, Instituto Ramón y Cajal de Investigación Sanitaria-IRYCIS, Ramon y Cajal Hospital, 28034 Madrid, Spain.ORCID 0000-0003-4551-6353
Ángela Hermosa-GelbardDermatology Department, Instituto Ramón y Cajal de Investigación Sanitaria-IRYCIS, Ramon y Cajal Hospital, 28034 Madrid, Spain.ORCID 0000-0002-0152-9526
Bárbara Burgos-BlascoOphthalmology Department, Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain.ORCID 0000-0003-2178-6164
Patricia Burgos-BlascoDermatology Department, Instituto Ramón y Cajal de Investigación Sanitaria-IRYCIS, Ramon y Cajal Hospital, 28034 Madrid, Spain.ORCID 0000-0002-4517-507X
Sergio Vañó-GalvánDermatology Department, Instituto Ramón y Cajal de Investigación Sanitaria-IRYCIS, Ramon y Cajal Hospital, 28034 Madrid, Spain.ORCID 0000-0003-2773-7494
David Saceda-CorraloDermatology Department, Instituto Ramón y Cajal de Investigación Sanitaria-IRYCIS, Ramon y Cajal Hospital, 28034 Madrid, Spain.ORCID 0000-0001-6315-5462

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alopecia areata (AA) is a complex disease with a multifactorial etiology, in which autoimmune mechanisms play a central role. Increasing evidence suggests that AA may be a systemic condition, potentially affecting organs beyond the skin due to shared pathogenic pathways. One proposed mechanism is the breakdown of immune privilege, a protective state that limits immune activity in specific tissues, such as the hair follicle and the eye. Although research on the relationship between AA and ophthalmic comorbidities remains limited, several studies have reported recurrent ocular abnormalities, whether subclinical or symptomatic, appearing at younger ages than typically observed in the general population. This review aims to summarize current knowledge on the association between AA and ocular involvement, exploring shared pathogenic mechanisms, clinical eye manifestations, and practical considerations for addressing ocular symptoms in dermatological practice.

Indexed as

alopecia areatacomorbidityimmune privilegeophthalmology

Identifiers

PMID41375713
PMCPMC12693123

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.