Evidence map›Paper›PMID 41375425›Full record

ArticleAnimals : an open access journal from MDPI2025

Comparison of Virtual Non-Contrast Images Generated by Spectral Detector Computed Tomography and Conventional Computed Tomography Images of Histologically Confirmed Hepatic Pathologies in 28 Dogs.

Lydia K Claußen, Alkje M van Gemmeren, Philipp Lietz, Sebastian Meller, Adriano Wang-Leandro, Andreas Beineke, Verena Nerschbach, Holger A Volk, Kristina Merhof

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lydia K ClaußenDepartment of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.ORCID 0009-0006-4550-0748
Alkje M van GemmerenDepartment of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.ORCID 0009-0007-5518-7748
Philipp LietzDepartment of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
Sebastian MellerDepartment of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
Adriano Wang-LeandroDepartment of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
Andreas BeinekeDepartment of Pathology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
Verena NerschbachDepartment of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
Holger A VolkDepartment of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.ORCID 0000-0002-7312-638X
Kristina MerhofDepartment of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.ORCID 0000-0002-9386-3096

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spectral detector computed tomography (SDCT) is an innovative imaging technique in veterinary medicine that utilises simultaneous data acquisition at different energy levels using two rows of detectors. This technique provides several interesting applications which improve insights into tissue composition. One implementation is the generation of virtual non-contrast (VNC) images from post-contrast spectral CT data by identifying and subtracting iodine pixels. Preliminary studies suggest that VNC images may offer diagnostic quality comparable to true unenhanced (TUE) images in healthy dogs; however, this technique has yet to be evaluated in clinical patients. This study compared the Hounsfield units (HUs) measured in VNC to those in TUE images of canine hepatic pathologies, taking into account specific types of pathologies based on their imaging characteristics. The attenuation values of the VNC and TUE series were analysed using two one-sided

Indexed as

dual-energyhepatopathyspectral-based imagesspectral detector computed tomography (SDCT)true unenhanced (TUE) imagesvirtual non-contrast (VNC)

Identifiers

PMID41375425
PMCPMC12691462

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.