Evidence map›Paper›PMID 41375155›Full record

ArticleMolecules (Basel, Switzerland)2025

Antiprotozoal Aminosteroid Alkaloids from

Justus Wambua Mukavi, Monica Cal, Marcel Kaiser, Pascal Mäser, Njogu M Kimani, Leonidah Kerubo Omosa, Thomas J Schmidt

Erratum issuedAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Justus Wambua MukaviUniversity of Münster, Institute of Pharmaceutical Biology and Phytochemistry (IPBP), PharmaCampus, Corrensstraße 48, D-48149 Münster, Germany.ORCID 0000-0001-9638-3250
Monica CalSwiss Tropical and Public Health Institute (Swiss TPH), Kreuzstrasse 2, CH-4123 Allschwil, Switzerland.ORCID 0009-0007-9959-9891
Marcel KaiserSwiss Tropical and Public Health Institute (Swiss TPH), Kreuzstrasse 2, CH-4123 Allschwil, Switzerland.ORCID 0000-0003-1785-7302
Pascal MäserSwiss Tropical and Public Health Institute (Swiss TPH), Kreuzstrasse 2, CH-4123 Allschwil, Switzerland.ORCID 0000-0003-3122-1941
Njogu M KimaniDepartment of Physical Sciences, University of Embu, Embu P.O. Box 6-60100, Kenya.ORCID 0000-0002-5171-1940
Leonidah Kerubo OmosaDepartment of Chemistry, Faculty of Science & Technology, University of Nairobi, Nairobi P.O. Box 30197-00100, Kenya.ORCID 0000-0002-5821-8307
Thomas J SchmidtUniversity of Münster, Institute of Pharmaceutical Biology and Phytochemistry (IPBP), PharmaCampus, Corrensstraße 48, D-48149 Münster, Germany.ORCID 0000-0003-2634-9705

Funding

Apothekerstiftung Westfalen-Lippe Project title: Struktur-Wirkungsbeziehungen für die antiprotozoale Aktivität von Aminosteroiden und Amino-nortriterpenen aus Buxaceae und Apocynaceae; no grant numberKenyan National Research Fund-Kenya in cooperation with the German Academic Exchange Service (NRF-DAAD). Doctoral fellowship for Mr. Justus Wambua Mukavi, no grant number.
6 · The paper itself

Abstract

Human African Trypanosomiasis (HAT; sleeping sickness) and Malaria are life-threatening protozoan infections in tropical regions, with limited treatment options. As part of our ongoing efforts to discover new aminosteroid alkaloids from the Buxaceae family with antiprotozoal activity, which might serve as leads to new drugs against these infections, we investigated the dichloromethane extract from the leaves of

Indexed as

AlkaloidsAntiprotozoal AgentsBuxusHumansMolecular StructurePlant ExtractsPlant LeavesPlasmodium falciparumTrypanosoma brucei rhodesienseAlkaloidsAntiprotozoal AgentsPlant Extractsaminosteroid alkaloidsBuxaceaeBuxus obtusifolia (Mildbr.) Hutch.natural productsPlasmodium falciparumTrypanosoma brucei rhodesiense

Identifiers

PMID41375155
PMCPMC12693156

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.