Evidence map›Paper›PMID 41375125›Full record

ArticleMolecules (Basel, Switzerland)2025

Synthesis and Evaluation of Radiogallium-Labeled Peptide Probes for In Vivo Imaging of Legumain Activity.

Takeshi Fuchigami, Kohnosuke Itagaki, Sakura Yoshida, Morio Nakayama, Masayuki Munekane, Kazuma Ogawa

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Takeshi FuchigamiLaboratory of Clinical Analytical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Ishikawa, Japan.ORCID 0000-0001-8141-1212
Kohnosuke ItagakiDepartment of Hygienic Chemistry, Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Nagasaki, Japan.
Sakura YoshidaFaculty of Environmental Engineering, The University of Kitakyushu, Kitakyushu 802-8577, Fukuoka, Japan.ORCID 0000-0002-5198-4711
Morio NakayamaDepartment of Hygienic Chemistry, Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Nagasaki, Japan.
Masayuki MunekaneLaboratory of Clinical Analytical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Ishikawa, Japan.ORCID 0000-0002-3405-4512
Kazuma OgawaLaboratory of Clinical Analytical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Ishikawa, Japan.ORCID 0000-0002-1691-7302

Funding

Hitachi Global Foundation No numberHokkoku Cancer Foundation No numberJapan Science and Technology Agency JPMJFR200VJapan Society for the Promotion of Science 22H03015, 15K09895, 18K07756Kanazawa University SAKIGAKE project 2022 and 2024Kieiotoyo Foundation No numberKobayashi Foundation for Cancer Research No numberNakatomi Foundation No numberNOVARTIS Foundation for the Promotion of Science (Japan) No numberShibuya Science Culture and Sports foundation No numberShimadzu Science Foundation No numberTakeda Science Foundation No mumberTerumo life science foundation No number
6 · The paper itself

Abstract

Legumain (LGMN), a lysosomal cysteine protease, is crucial for tumor progression, invasion, and metastasis, making it a promising target for cancer imaging and therapy. This study developed novel

Indexed as

Cysteine EndopeptidasesGallium RadioisotopesPeptidesRadiopharmaceuticalsAnimalsAsparaginyl EndopeptidaseHCT116 CellsHeterocyclic Compounds, 1-RingHumansMiceTissue Distribution1,4,7-triazacyclononane-N,N',N''-triacetic acidAsparaginyl EndopeptidaseCysteine EndopeptidasesGallium RadioisotopesHeterocyclic Compounds, 1-RingPeptidesRadiopharmaceuticalsactivatable cell penetrating peptidecancer imaginglegumainradiogalliumSPECT

Identifiers

PMID41375125
PMCPMC12693633

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.