Evidence map›Paper›PMID 41375108›Full record

ArticleMolecules (Basel, Switzerland)2025

High-Resolution Electrospray and Ion Mobility Sequential Mass Spectrometry for Structural Characterisation of Anticancer Stem Cell Agent Salinomycin and Its Isomers.

Candy Jiang, Paul J Gates

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Candy JiangSchool of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.ORCID 0000-0002-8469-1122
Paul J GatesSchool of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.ORCID 0000-0001-8619-7745

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Salinomycin is a polyether ionophore natural product widely studied for its anticancer stem cell properties and well established anti-coccidial activity. However, its complex structure and tendency to isomerise in solution complicates its mass spectrometric analysis. In this study, a combination of high-resolution accurate mass electrospray sequential mass spectrometry, ion mobility spectrometry and computational modelling was employed to analyse salinomycin and its isomers for the first time. Product ions generated from salinomycin and its isomer in the MS

Indexed as

Antineoplastic AgentsIon Mobility SpectrometryNeoplastic Stem CellsPyransSpectrometry, Mass, Electrospray IonizationHumansIsomerismMolecular StructurePolyether PolyketidesAntineoplastic AgentsPolyether PolyketidesPyranssalinomycinion mobility mass spectrometrypolyether ionophoressalinomycinsequential mass spectrometry

Identifiers

PMID41375108
PMCPMC12693351

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.