Evidence map›Paper›PMID 41375102›Full record

ArticleMolecules (Basel, Switzerland)2025

NXC736, a Functional Antagonist of S1P

Nikita Basnet, Supriya Tiwari, Kyung Hee Choi, Donghee Kim, Ji Woong Choi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nikita BasnetCollege of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, 191 Hambakmoero, Yeonsu-gu, Incheon 21936, Republic of Korea.
Supriya TiwariCollege of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, 191 Hambakmoero, Yeonsu-gu, Incheon 21936, Republic of Korea.
Kyung Hee ChoiCollege of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, 191 Hambakmoero, Yeonsu-gu, Incheon 21936, Republic of Korea.ORCID 0000-0002-9532-1581
Donghee KimCollege of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, 191 Hambakmoero, Yeonsu-gu, Incheon 21936, Republic of Korea.ORCID 0000-0001-8773-6528
Ji Woong ChoiCollege of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, 191 Hambakmoero, Yeonsu-gu, Incheon 21936, Republic of Korea.

Funding

National Research Foundation of Korea NRF-2021R1A2C1005520National Research Foundation of Korea RS-2020-NR049589National Research Foundation of Korea RS-2025-16066207
6 · The paper itself

Abstract

Stroke is the leading cause of death and long-term disability worldwide, with ischemic stroke accounting for nearly 87% of all cases. Vascular occlusion, a key pathological event in ischemic stroke, has been reliably reproduced in preclinical studies using permanent ischemic stroke models. This study demonstrated the neuroprotective effect of NXC736, a functional antagonist of sphingosine-1-phosphate receptor 4 (S1P

Indexed as

Brain InjuriesIschemic StrokeNeuroprotective AgentsAnimalsApoptosisBlood-Brain BarrierDisease Models, AnimalInfarction, Middle Cerebral ArteryMaleMiceMice, Inbred C57BLMicrogliaNF-kappa BOxidative StressSphingosine-1-Phosphate ReceptorsNeuroprotective AgentsNF-kappa BSphingosine-1-Phosphate ReceptorsNXC736permanent ischemic strokepermanent middle cerebral artery occlusion (pMCAO)S1P4

Identifiers

PMID41375102
PMCPMC12693047

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.