Evidence map›Paper›PMID 41375088›Full record

ArticleCancers2025

Enhancing PRRT Outcome Prediction in Neuroendocrine Tumors: Aggregated Multi-Lesion PET Radiomics Incorporating Inter-Tumor Heterogeneity.

Maziar Sabouri, Ghasem Hajianfar, Omid Gharibi, Alireza Rafiei Sardouei, Yusuf Menda, Ayca Dundar, Camila Gadens Zamboni, Sanchay Jain, Marc Kruzer, Habib Zaidi and 3 more

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Real-world experience of clinicopathological features and survival predictors in radioactive iodine-refractory differentiated thyroid cancer treated with multi-kinase inhibitors: a multicentre study from southeastern Spain.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Maziar SabouriDepartment of Physics and Astronomy, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Ghasem HajianfarDivision of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, 1205 Geneva, Switzerland.ORCID 0000-0001-5359-2407
Omid GharibiDepartment of Physics and Astronomy, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.ORCID 0000-0003-3403-9168
Alireza Rafiei SardoueiDepartment of Electrical and Computer Engineering, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Yusuf MendaDivision of Nuclear Medicine, Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Ayca DundarDivision of Nuclear Medicine, Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Camila Gadens ZamboniDivision of Nuclear Medicine, Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.ORCID 0000-0002-2365-7908
Sanchay JainDivision of Nuclear Medicine, Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Marc KruzerMIM Software Inc., Cleveland, OH 44122, USA.
Habib ZaidiDivision of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, 1205 Geneva, Switzerland.ORCID 0000-0001-7559-5297
Fereshteh YousefiriziDepartment of Basic and Translational Research, BC Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.ORCID 0000-0001-5261-6163
Arman RahmimDepartment of Physics and Astronomy, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.ORCID 0000-0002-9980-2403
Ahmad ShariftabriziDivision of Nuclear Medicine, Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.ORCID 0000-0003-2397-6914

Funding

Project 3: GLP1R and GIPR Agonists in GEP NETs ProjectP50CA302572 · NCI · UNIVERSITY OF IOWA · PI JAMES R HOWE · 2025 to 2026
$6.5M
CIHR PJT-173231Natural Sciences and Engineering Research Council of Canada DH-2025-00119NCI NIH HHS P50 CA302572
6 · The paper itself

Abstract

introductionPeptide Receptor Radionuclide Therapy (PRRT) with [

methodsEighty-one NETs patients with multiple lesions underwent pre-treatment PET/CT imaging. Lesions were segmented and ranked by minimum Standard Uptake Value (SUV

resultsThe overall appraisal showed that sorting lesions based on SUV

conclusionsThis study demonstrates that informed lesion selection and tailored aggregation strategies significantly impact the predictive performance of radiomics-based models for progression and TTP prediction in PRRT-treated NET patients. These approaches can potentially enhance model accuracy and better capture tumor heterogeneity, supporting more personalized and practical PRRT implementation.

Indexed as

feature aggregationNeuroendocrine TumorsPETPRRTradiomics

Identifiers

PMID41375088
PMCPMC12690984

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.