Evidence map›Paper›PMID 41375005›Full record

ArticleCancers2025

Personalized Circulating Tumor DNA Assay to Assess Long-Term Clinical Benefit in Patients with Advanced Melanoma.

Clara Martínez-Vila, Cristina Teixido, Roberto Martín, Francisco Aya, Sumedha Sudhaman, Griffin L Budde, Europa Azucena González-Navarro, Llucia Alos, Natalia Castrejon, J Bryce Ortiz and 3 more

Registry-linked trialAbstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07689812 (A Multicenter Randomized Open-Label Trial Evaluating ctDNA-Guided Interruption Versus Standard of Care Continuous Immune-Checkpoint Inhibitor), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07689812 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Multicenter Randomized Open-Label Trial Evaluating ctDNA-Guided Interruption Versus Standard of Care Continuous Immune-Checkpoint Inhibitor (ICI) Therapy In Patients With Advanced/Metastatic Solid Tumors

TypeinterventionalSponsorNatera, Inc.Ran2026 to 2034Enrolled920ConditionsNSCLC (Advanced Non-small Cell Lung Cancer), NSCLC (Non-small Cell Lung Cancer), NSCLC (Non-small Cell Lung Carcinoma), NSCLCArmsSignatera Genome ultra-sensitive ctDNA blood test
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Clara Martínez-VilaDepartment of Medical Oncology, Hospital Clínic of Barcelona, Villarroel 170, 08036 Barcelona, Spain.
Cristina TeixidoMolecular Biology CORE Laboratory, Biomedical Diagnostic Centre (CDB), Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain.ORCID 0000-0002-7226-6567
Roberto MartínDepartment of Medical Oncology, Hospital Clínic of Barcelona, Villarroel 170, 08036 Barcelona, Spain.
Francisco AyaDepartment of Medical Oncology, Hospital Clínic of Barcelona, Villarroel 170, 08036 Barcelona, Spain.ORCID 0000-0002-3452-7607
Sumedha SudhamanNatera, Inc., Austin, TX 78753, USA.
Griffin L BuddeNatera, Inc., Austin, TX 78753, USA.
Europa Azucena González-NavarroAugust Pi i Sunyer Biomedical Research Institute (IDIBAPS), Rosselló 149, 08036 Barcelona, Spain.ORCID 0000-0003-3310-5557
Llucia AlosDepartment of Pathology, Hospital Clínic of Barcelona, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain.ORCID 0000-0002-3460-0384
Natalia CastrejonDepartment of Pathology, Hospital Clínic of Barcelona, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain.ORCID 0000-0002-0647-3058
J Bryce OrtizNatera, Inc., Austin, TX 78753, USA.ORCID 0000-0002-3126-9171
Michael KrainockNatera, Inc., Austin, TX 78753, USA.
Minetta C LiuNatera, Inc., Austin, TX 78753, USA.ORCID 0000-0002-8206-5232
Ana AranceDepartment of Medical Oncology, Hospital Clínic of Barcelona, Villarroel 170, 08036 Barcelona, Spain.ORCID 0000-0003-2896-1957

Funding

Sociedad Española de Oncología Médica SEOM_PrinmunoOnco20
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

advanced melanomaanti-PD-1biomarkerctDNAimmunotherapylong-term outcomespersonalized assaytreatment duration

Identifiers

PMID41375005
PMCPMC12691311

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.