Evidence map›Paper›PMID 41374959›Full record

ReviewCancers2025

The Effect of Tumor Location and Extension on Survival in Patients with Sinonasal Mucosal Melanoma: A Systematic Review and Meta-Analysis.

Fan Yang, Marina Ruiz Cifuentes, Peter Horvatovich, Victor Guryev, Eszter Baltás, Gilles F H Diercks, Alienke van Pijkeren, Inge Wegner, Gyorgy B Halmos

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fan YangDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Marina Ruiz CifuentesDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Peter HorvatovichDepartment of Analytical Biochemistry, Faculty of Science and Engineering, University of Groningen, 9713 AV Groningen, The Netherlands.ORCID 0000-0003-2218-1140
Victor GuryevEuropean Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands.
Eszter BaltásDepartment of Dermatology and Allergology, University of Szeged, 6720 Szeged, Hungary.ORCID 0000-0003-0357-7393
Gilles F H DiercksDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Alienke van PijkerenDepartment of Analytical Biochemistry, Faculty of Science and Engineering, University of Groningen, 9713 AV Groningen, The Netherlands.ORCID 0000-0001-6830-0606
Inge WegnerDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.ORCID 0000-0002-4124-7224
Gyorgy B HalmosDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.ORCID 0000-0003-2460-2260

Funding

Dutch Research Council (NWO) project number 184.034.019the China Scholarship Council (CSC) project number 202306790022
6 · The paper itself

Abstract

BACKGROUND/

objectivesSNMM is a rare and aggressive malignancy with a poor prognosis. The current staging systems fail to adequately stratify patient risk. This study aimed to evaluate the prognostic impact of tumor location and extension on overall survival (OS) in SNMM.

methodsA systematic literature search of Medline, Web of Science, and Embase was performed to identify studies assessing the prognostic significance of tumor location and extension. Study quality was evaluated using the Quality in Prognosis Studies (QUIPS-2) tool. Meta-analyses were conducted to calculate pooled hazard ratios (HRs) with 95% confidence intervals (CIs). Eligible studies included primary SNMM reporting tumor location/extension and survival; observational designs (case series ≥ 5 patients) were eligible with no language restrictions. Searches covered MEDLINE, Web of Science, and Embase and were last updated on 10 Jan 2025; reference lists were also screened.

resultsThirty-four studies were included in the systematic review, of which ten met criteria for meta-analysis. Tumors located in the paranasal sinuses (HR = 2.89, 95% CI: 1.63-5.14) and those with orbital involvement (HR = 1.92, 95% CI: 1.34-2.73) were associated with significantly poorer OS. Maxillary and ethmoid sinus involvement showed no statistically significant difference compared with nasal cavity tumors.

conclusionsTumor location and extension are significant prognostic indicators in SNMM. Patients with paranasal sinus tumors or orbital invasion have worse outcomes, supporting inclusion of these factors in future staging systems for better clinical decision-making. Limitations include the observational nature of the evidence, heterogeneity across definitions and analyses, and underpowered publication-bias tests; certainty of evidence was not formally graded.

Indexed as

meta-analysisoverall survivalprognosissinonasal mucosal melanomatumor extensiontumor location

Identifiers

PMID41374959
PMCPMC12691534

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.