Evidence map›Paper›PMID 41374957›Full record

ArticleCancers2025

Germline Variants in the Immune Response-Related Genes: Possible Modifying Effect on Age-Dependent

Ekaterina S Kuligina, Aleksandr S Martianov, Grigory A Yanus, Yuliy A Gorgul, Evgeny N Suspitsin, Alexandr A Romanko, Anastasia V Tumakova, Alexandr V Togo, Aniruddh Kashyap, Cezary Cybulski and 2 more

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ekaterina S KuliginaLaboratory of Molecular Oncology, Department of Tumor Growth Biology, N.N. Petrov National Medical Research Center of Oncology, Saint Petersburg 197758, Russia.ORCID 0000-0002-2396-6540
Aleksandr S MartianovLaboratory of Molecular Oncology, Department of Tumor Growth Biology, N.N. Petrov National Medical Research Center of Oncology, Saint Petersburg 197758, Russia.ORCID 0000-0002-7690-8328
Grigory A YanusLaboratory of Molecular Oncology, Department of Tumor Growth Biology, N.N. Petrov National Medical Research Center of Oncology, Saint Petersburg 197758, Russia.ORCID 0000-0002-9844-4536
Yuliy A GorgulLaboratory of Molecular Oncology, Department of Tumor Growth Biology, N.N. Petrov National Medical Research Center of Oncology, Saint Petersburg 197758, Russia.
Evgeny N SuspitsinLaboratory of Molecular Oncology, Department of Tumor Growth Biology, N.N. Petrov National Medical Research Center of Oncology, Saint Petersburg 197758, Russia.
Alexandr A RomankoLaboratory of Molecular Oncology, Department of Tumor Growth Biology, N.N. Petrov National Medical Research Center of Oncology, Saint Petersburg 197758, Russia.ORCID 0000-0002-6549-8378
Anastasia V TumakovaDepartment of Medical Genetics, Saint Petersburg State Pediatric Medical University, Saint Petersburg 194100, Russia.
Alexandr V TogoLaboratory of Molecular Oncology, Department of Tumor Growth Biology, N.N. Petrov National Medical Research Center of Oncology, Saint Petersburg 197758, Russia.
Aniruddh KashyapInternational Hereditary Cancer Center, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland.
Cezary CybulskiInternational Hereditary Cancer Center, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland.ORCID 0000-0002-2819-3057
Jan LubińskiInternational Hereditary Cancer Center, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland.ORCID 0000-0003-2931-3003
Evgeny N ImyanitovLaboratory of Molecular Oncology, Department of Tumor Growth Biology, N.N. Petrov National Medical Research Center of Oncology, Saint Petersburg 197758, Russia.ORCID 0000-0003-4529-7891

Funding

Russian Science Foundation 22-15-00278
6 · The paper itself

Abstract

background

methodsCase-control comparison of BC-affected versus non-affected

resultsNGS for 353 genes implicated in inborn errors of immunity was performed on 42 young-onset (<39 y.o.) and 35 late-onset (>57 y.o.) BC patients carrying

conclusionsRare variants in immune-related genes, such as

Indexed as

age at onsetantitumor immunityBRCA1breast cancergermline mutationsinherited cancer riskmutation penetrancePRF1

Identifiers

PMID41374957
PMCPMC12691255

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