ArticleCancers2025
Inverse Association Between METS-IR and Lung Cancer Risk: The Role of BMI in a Nationwide Korean Cohort.
Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Associations of metabolic score for insulin resistance with type 2 diabetes, cancer, and all-cause mortality: a meta-analysis of cohort studies.Frontiers in endocrinology · 2026Pooled it
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough insulin resistance has been implicated in cancer development, its specific role in lung cancer remains unclear. The metabolic score for insulin resistance (METS-IR) is a novel surrogate marker that integrates multiple metabolic parameters and has demonstrated strong predictive value for metabolic disorders. This study aimed to investigate the association between METS-IR and lung cancer incidence in a large-scale nationwide cohort.
methodsWe analyzed data from 322,624 participants of the National Health Insurance Service-National Health Screening Cohort in Republic of Korea. Participants were stratified into METS-IR quartiles, and lung cancer incidence was assessed using Kaplan-Meier survival curves and Cox proportional hazards regression models. Subgroup analyses were conducted to examine the impact of body composition, particularly sarcopenia, on the association between METS-IR and lung cancer.
resultsOver a median follow-up of 9.5 years, 5912 lung cancer cases were identified. Lung cancer incidence per 1000 person-years was highest in the lowest METS-IR quartile (Q1: 2.27) and decreased across quartiles (Q2: 1.93, Q3: 1.81, Q4: 1.72). In fully adjusted Cox regression models, using Q1 as the reference group, higher METS-IR quartiles were associated with a significantly lower risk of lung cancer (Q2: HR 0.91, 95% CI 0.85-0.98; Q3: HR 0.86, 95% CI 0.79-0.92; Q4: HR 0.80, 95% CI 0.74-0.86;
conclusionsIn this nationwide cohort study, we observed a significant inverse association between METS-IR and lung cancer risk. However, METS-IR showed limitations in fully explaining lung cancer risk based on insulin resistance alone. These findings highlight the need for future studies incorporating body composition assessments to better evaluate metabolic vulnerability.
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